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Long-term toxicity to fish

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Description of key information

No data on long-term toxicity on fish are available. However, the chemical safety assessment clearly indicates no need to investigate further the effects of Propan-1-ol to fish. 

Key value for chemical safety assessment

Additional information

In Annex IX of Regulation (EC) No 1907/2006, it is laid down that chronic toxicity tests shall be proposed by the registrant if the chemical safety assessment indicates the need to investigate further the effects on fish. According to Annex I of this regulation, the chemical safety assessment triggers further action when the substance or the preparation meets the criteria for classification as dangerous according to Directive 67/548/EEC or Directive 1999/45/EC or is assessed to be a PBT or vPvB. The hazard assessment of Propan-1 -ol reveals neither a need to classify the substance as dangerous to the environment, nor PBT or vPvB properties. Moreover there are no further indications that the substance may be chronic hazardous to the environment. This is supported by a study on the chonic toxicity of the structurally similar substance 2 -Propanol (CAS: 67-63-0) to Daphnia magna (performed according to OECD guideline 211 under GLP conditions), revealing no reproductive effects at concentrations up to 100 mg/l (NOEC > 100 mg/l). A prolonged toxicity test to fish conducted with 2 -Propanol (performed according to OECD guideline 204 under GLP conditions with 14 days test duration), revealed as well no effects at 100 mg/l (NOEC > 100 mg/l). Therefore, and for reasons of animal welfare, a long-term toxicity study in fish is not provided.