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EC number: 200-746-9 | CAS number: 71-23-8
Toxicological information
Basic toxicokinetics
Currently viewing:
Administrative data
- Endpoint:
- basic toxicokinetics in vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- publication
- Title:
- Absorption, distribution and metabolism of propyl anthranilate.
- Author:
- Fahelbum I.M.S. and James S.P
- Year:
- 1 979
- Bibliographic source:
- Toxicology, 12: 75-87
Materials and methods
- Objective of study:
- absorption
- distribution
- excretion
- Principles of method if other than guideline:
- Wistar rats were dosed by gavage with 14C-labelled propan-1-ol. Urine, faeces and expired CO2 were collected and examined. Further more radioactivity in the blood and tissue distribution were determined.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Propan-1-ol
- EC Number:
- 200-746-9
- EC Name:
- Propan-1-ol
- Cas Number:
- 71-23-8
- Molecular formula:
- C3H8O
- IUPAC Name:
- propan-1-ol
Constituent 1
- Specific details on test material used for the study:
- - Source: obtained from the Radiochemical Centre Ltd ., Amersham, U .K
- Analytical purity: no data - Radiolabelling:
- yes
- Remarks:
- 14 C
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- - Body weight initation: 250-400g
- Diet: maintained on the Heygate's modified rat/mouse breeding diet
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Duration and frequency of treatment / exposure:
- single dose application
Doses / concentrations
- Remarks:
- Doses / Concentrations:
174 mg/ rat
- No. of animals per sex per dose / concentration:
- no data
- Control animals:
- not specified
- Details on dosing and sampling:
Determination of radioactivity in blood of rats dosed with 14C-labelled propan-l-o l:
Rats were dosed with 14C-labelled compounds (1.6-9.1 µCi/rat); 2.9 mmol/kg body wt for propan-l-ol. Blood samples (1 ml) were taken from the tail vein at intervals after the dose, (5, 15, 30, 60, 120, 240, 360, 480, 1140 min), not more than 3 samples being taken from any 1 rat. The blood samples were diluted to 25 ml with water and triplicate aliquots ( 1 ml) were pipetted into counting vials. Soluene was added to digest the protein. The radioactivity was counted using a Philips Automatic Liquid Scintillation Analyser
Determination of Urinary metabolites:
Urine and faeces were collected after each 24 h; expired 14CO2 trapped in 2 M-KOH. The radioactivity of samples Control samples of urine, faecal extract and diluted 2 M-KOH were also counted. Time-course curves for the excretion of 14CO2 were plotted and used to calculate the velocity constants for the elimination of the dose and for the excretion of 14CO2 as described by Bray et al 1950 and 1951
Distribution of radioactivity in rat tissues:
The amount of radioactivity given to each rat was 8.8-9.6 µCi. At 2 h or 6 h after dosing blood samples (1 ml) were taken and then the rats were killed For each compound 4 rats were dosed, 2 being killed at 2 h and 2 at 6 h after the doses were administered. The livers, hearts, kidneys and brains were removed and weighed. The level of radioactivity of duplicate weighed samples (approx . 300 mg) was measured by combustion and measurement of the 14CO2 produced using the Harvey Biological Material Oxidiser (ICN Tracerlab Ltd., Hersham,). In control, determinations combustion of weighed amounts of [14C] mannitol (Radiochemical Centre, Amersham, Bucks,) of known specific activity gave a recovery of 96-101%.
Results and discussion
Main ADME resultsopen allclose all
- Type:
- absorption
- Results:
- Propanol concentrations in blood peaked one hour after administration.
- Type:
- distribution
- Results:
- Six hours after oral dosing following distribution of radioactivity in tissues of rats (μmol of the dose/g tissue) was found: blood (0.4), brain (0.2), heart (0.3), kidney (0.7), liver (1.3).
- Type:
- excretion
- Results:
- Total recovery rate 72 hours after dosage was about 80% , with about 74% of the radioactivity being eliminated in expired air, 5% via the urine and 0.4% in faeces
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