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EC number: 200-746-9 | CAS number: 71-23-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
- Remarks:
- (1; 5; 15 min and 20 h occlusive exposure, no washing after 20h exposure, 8 day observation period only two animals), study prior to GLP
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 975
- Report date:
- 1975
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Deviations:
- yes
- Remarks:
- (1; 5; 15 min and 20 h exposure duration, occlusive exposure, no washing after 20h exposure, 8 day observation period)
- GLP compliance:
- no
Test material
- Reference substance name:
- Propan-1-ol
- EC Number:
- 200-746-9
- EC Name:
- Propan-1-ol
- Cas Number:
- 71-23-8
- Molecular formula:
- C3H8O
- IUPAC Name:
- propan-1-ol
- Test material form:
- liquid
Constituent 1
- Specific details on test material used for the study:
- Analytical purity: 99.5%
Test animals
- Species:
- rabbit
- Strain:
- Vienna White
- Details on test animals or test system and environmental conditions:
- - Source: Gaukler
- Body weight at study initiation: 2 males weighing 298 g each
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- shaved
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not specified
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume): 1 ml
- Concentration (if solution): undiluted (concentrated) - Duration of treatment / exposure:
- - Dorsal application: 1; 5; 15 min and 20 h
- Ear application: 20 h - Observation period:
- 8 days (in 24h intervals from day 1-4, then again on day 7 and on day 9
- Number of animals:
- 2
- Details on study design:
- TEST SITE
- Area of exposure: back; 2 x 2 cm, ear; 1 x 2 cm
REMOVAL OF TEST SUBSTANCE
- Washing: concentrated Lutrol and 50 % lutrol in water only after exposure for 1, 5, and 15 min
SCORING SYSTEM:
The BASF numerical skin grading system was converted to the scoring system by Draize. Scoring of skin changes was performed as following: day of application, then after 24h, 48h, 72h, 8d.
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Remarks:
- (15 min exposure)
- Basis:
- mean
- Remarks:
- (of 2 animals)
- Time point:
- other: 24h, 48h, 72h
- Score:
- 0.17
- Max. score:
- 4
- Reversibility:
- fully reversible
- Remarks on result:
- other: 15 minutes exposure: Very slight redness was seen in one animal 24 h post application. Redness was no longer present 24h later at the 48h observation time point
- Irritation parameter:
- edema score
- Remarks:
- (15 min exposure)
- Basis:
- mean
- Remarks:
- (of 2 animals)
- Time point:
- other: 24h, 48h, 72h
- Score:
- 0
- Max. score:
- 4
- Remarks on result:
- other: 15 minutes exposure
- Irritation parameter:
- erythema score
- Remarks:
- (20h exposure)
- Basis:
- mean
- Remarks:
- (of 2 animals)
- Time point:
- other: 24h, 48h, 72h
- Score:
- 0.33
- Max. score:
- 4
- Reversibility:
- fully reversible within: 8 days
- Remarks on result:
- other: 20 hours exposure
- Irritation parameter:
- edema score
- Remarks:
- (20 h expsoure)
- Basis:
- mean
- Remarks:
- (of 2 animals)
- Time point:
- other: 24h, 48h, 72h
- Score:
- 0
- Max. score:
- 4
- Remarks on result:
- other: 20 hours exposure: Flaky skin was observed in one of two animals 24h after application. Mild desquamation developed in the same animal by day 7 and was still present on day 9 at termination of the study
- Irritant / corrosive response data:
- RESULTS IN THE 1 MIN and 5 MIN EXPOSURE GROUPS
- Mean score erythema (2 animals, 24, 48, 72h): 0
- Mean score edema (2 animals, 24, 48, 72h): 0 - Other effects:
- Body weight at termination: 294 and 296 g, respectively
Any other information on results incl. tables
Table 1: Summary of Results after 15 mins
Readings |
Animal |
Erythema |
Edema |
Further findings |
24h |
1 |
0 |
0 |
|
2 |
1 |
0 |
||
48h |
1 |
0 |
0 |
|
2 |
0 |
0 |
||
72h |
1 |
0 |
0 |
|
2 |
0 |
0 |
||
8d |
1 |
0 |
0 |
|
2 |
0 |
0 |
||
Mean (24h-72h) |
1 |
0 |
0 |
|
2 |
0.33 |
0 |
||
Mean (24h-72h) |
All animals |
0.17 |
0 |
Table 2: Sumary of Results after 20 h
Readings |
Animal |
Erythema |
Edema |
Further findings |
24h |
1 |
0 |
0 |
- |
2 |
1 |
0 |
Flaky skin |
|
48h |
1 |
0 |
0 |
- |
2 |
0 |
0 |
- |
|
72h |
1 |
0 |
0 |
- |
2 |
1 |
0 |
- |
|
6d |
1 |
0 |
0 |
- |
2 |
1 |
0 |
Desquamation |
|
8d |
1 |
0 |
0 |
- |
2 |
0 |
0 |
Desquamation |
|
Mean (24h-72h) |
1 |
0 |
0 |
|
2 |
0.667 |
0 |
||
Mean (24h-72h) |
All animals |
0.333 |
0 |
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
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