Registration Dossier
Registration Dossier
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EC number: 220-941-2 | CAS number: 2943-75-1
Toxicity to terrestrial plants
Administrative data
Link to relevant study record(s)
- Endpoint:
- toxicity to terrestrial plants: long-term
- Type of information:
- experimental study planned
- Study period:
- After approval by ECHA
- Justification for type of information:
- Triethoxy(octyl)silane (CAS 2943-75-1) falls under soil Hazard Category 3 (indication for high adsorption based on log Kow >3, but no indication of aquatic toxicity (no effects in aquatic studies)). For Hazard Category 3 substances, a confirmatory long-term study is required: a confirmatory OECD TG 222 study was conducted. A 56-day EC10 value of 44.71 mg/kg dw was reported for effects of triethoxy(octyl)silane on reproduction of earthworms. ECHA guidance Chapter R.7c (ECHA 2017) states the following: “If PEC/PNECscreen >1 or indication of risk from confirmatory long-term soil toxicity test: Conduct long-term toxicity tests according to the standard information requirements Annex X (invertebrates and plants), choose lowest value for derivation of PNECsoil”.
In accordance with the ECHA guidance, because effects were observed in the OECD TG 222 earthworm study, as well as the soil microorganisms study (28-day NOEC 320 mg/kg dw), a long-term toxicity to terrestrial plants study is required.
A long-term toxicity to terrestrial plants study in accordance with OECD TG 208 is therefore proposed with triethoxy(octyl)silane (CAS 2943-75-1, EC No. 220-941-2). - Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 208 (Terrestrial Plants Test: Seedling Emergence and Seedling Growth Test)
Reference
Description of key information
Key value for chemical safety assessment
Additional information
No toxicity to terrestrial plants data are available with the registered substance (triethoxy(octyl)silane (CAS 2943-75-1, EC No. 220-941-2)).
Triethoxy(octyl)silane (CAS 2943-75-1) falls under soil Hazard Category 3 (indication for high adsorption based on log Kow >3, but no indication of aquatic toxicity (no effects in aquatic studies)). For Hazard Category 3 substances, a confirmatory long-term study is required: a confirmatory OECD TG 222 study was conducted. A 56-day EC10 value of 44.71 mg/kg dw was reported for effects of triethoxy(octyl)silane on reproduction of earthworms. ECHA guidance Chapter R.7c (ECHA 2017) states the following: “If PEC/PNECscreen >1 or indication of risk from confirmatory long-term soil toxicity test: Conduct long-term toxicity tests according to the standard information requirements Annex X (invertebrates and plants), choose lowest value for derivation of PNECsoil”.
In accordance with the ECHA guidance, because effects were observed in the OECD TG 222 earthworm study, as well as the soil microorganisms study (28-day NOEC 320 mg/kg dw), a long-term toxicity to terrestrial plants study is required.
A long-term toxicity to terrestrial plants study in accordance with OECD TG 208 is therefore proposed with triethoxy(octyl)silane (CAS 2943-75-1, EC No. 220-941-2) and is awaiting approval by ECHA.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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