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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Environmental fate & pathways

Bioaccumulation: aquatic / sediment

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Administrative data

Link to relevant study record(s)

Description of key information

According to REACH Annex IX, 9.3.2, column 2 the bioaccumulation study does not need to be conducted if the substance has a low potential for bioaccumulation. Rapid hydrolysis of the substance makes approximation of equilibrium in the environment impossible resulting in a low potential for bioaccumulation. For the bioaccumulation potential of the hydrolysis products see the discussion below.

Key value for chemical safety assessment

Additional information

According to experience with the substance itself as well as with similar polyisocyanates, the amines formed in the initial hydrolysis step, which is associated with elimination of carbon dioxide, have a high reactivity towards unreacted isocyanate. The consequence is that in the hydrolysis of isophorone diisocyanate oligomer predominantly polyurea molecules are formed. They are insoluble in water and they cannot bioaccumulate due to the absence of sufficient mobility. Therefore not only the substance itself but also its hydrolysis products have a low potential for bioaccumulation.