Registration Dossier

Diss Factsheets

Administrative data

Hazard for aquatic organisms

Freshwater

Hazard assessment conclusion:
no hazard identified

Marine water

Hazard assessment conclusion:
no hazard identified

STP

Hazard assessment conclusion:
no hazard identified

Sediment (freshwater)

Hazard assessment conclusion:
no exposure of sediment expected

Sediment (marine water)

Hazard assessment conclusion:
no exposure of sediment expected

Hazard for air

Air

Hazard assessment conclusion:
no hazard identified

Hazard for terrestrial organisms

Soil

Hazard assessment conclusion:
no exposure of soil expected

Hazard for predators

Secondary poisoning

Hazard assessment conclusion:
no potential for bioaccumulation

Additional information

Conclusion on classification

Directive 67/548/ECC

Based on the available ecotoxictiy data (fish, Daphnia, alga) IPDI oligomers and their hydrolysis products are not environmentally classified as dangerous according to Directive 67/548/EEC. No acute toxicity was recorded for any trophic level when testing saturated solutions. Based on available Environmental Fate data the classification “R53 May cause long-term adverse effects in the aquatic environment” may be considered. This classification (R53) applies to non-readily biodegradable substances with a very low water solubility (<1 mg/l) and accounts for the bioaccumulation and biomagnification potential that may arise from persistent substances. However, this classification is not considered appropriate for the present substance for the following reasons:

  • The registered substance is not found to be readily biodegradable, but exhibits a dissipation time in water less than the cut-off value of 12 h and is therefore considered as hydrolytically unstable.
  • Upon contact with water the diisocyanate groups of IPDI trimer react by forming amines and CO2. The amines formed react further with unreacted diisocyanate groups of IPDI homopolymer resulting in oligo- and subsequently polyurea components. Polyurea is known to be inert and is probably due to its molecular size not bioavailable. The parent substance has an average molecular weight of 893 g / mol (residual monomers are negligible). According to ECHA guidance on information requirements a molecular weight higher than 700 g/Mol indicates that the BCF is below 5000 L/kg. It can be concluded from the structural formulae that the formed polyurea has a molecular weight amounting to multiples of that of the initial oligomers. Polyurea is therefore considered as less bioaccumulative compared to the parent substance.
  • Moreover, a modelled Log Kow of 14.58 for the unhydrolysed parent substance indicates that the aquatic BCF is probably lower than 2000 L/kg (although this criterion should be treated with caution). Considering the above mentioned criteria the potential for bioaccumulation is regarded as minor for both the parent substance and the formed hydrolysis products.

GHS (Regulation 1272/2008/EEC)

Based on the available acute aquatic toxicity data and the arguments given above the substance is not classified.

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