Registration Dossier

Diss Factsheets

Administrative data

Description of key information

The GTN is GTN is harmful.
Tests skin irritation was made on rabits in vivo.
Tests eye irritation was made on rabits in vivo.
Undiluted nitroglycerin is a 'sensitive' high explosive and the danger of a major explosion of TNG vapors or mist in an inhalation study, with resulting major damage to personnel and facility, is too great to consider undertaking such a toxicological study

Key value for chemical safety assessment

Skin irritation / corrosion

Endpoint conclusion
Endpoint conclusion:
adverse effect observed (irritating)

Eye irritation

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not irritating)

Additional information

Undiluted nitroglycerin is a 'sensitive' high explosive and the danger of a major explosion of TNG vapors or mist in an inhalation study, with resulting major damage to personnel and facility, is too great to consider undertaking such a toxicological study


Effects on skin irritation/corrosion: slightly irritating

Effect level: empty Endpoint conclusion: Adverse effect observed

Justification for classification or non-classification

In accordance with section 1 of REACH Annex XI, the study (required in section 8.1) does not need to be conducted as the study „In vivo skin irritation“ exists.