Registration Dossier
Registration Dossier
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The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
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EC number: 907-605-7 | CAS number: 68815-47-4
Dermal absorption
Administrative data
- Endpoint:
- dermal absorption
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- supporting study
- Study period:
- no data
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Only secondary literature (evaluation and comparison of available data on alipathic amines)
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Reference
- Reference Type:
- publication
- Title:
- Toxicity of aliphatic amines: structure-activity relationship
- Author:
- Greim H, Bury D, Klimisch H J, Oeben-Negele M, Ziegler-Skylakakis K
- Year:
- 1 998
- Bibliographic source:
- Chemosphere, Volume 36, Issue 2, Pages 271–295
Materials and methods
- GLP compliance:
- not specified
Test material
- Reference substance name:
- aliphatic amines
- IUPAC Name:
- aliphatic amines
- Details on test material:
- Various aliphatic amines (17 primary, 11 secondary and 9 tertiary amines).
Constituent 1
Results and discussion
Any other information on results incl. tables
In general short chained amines (primary and secondary) are absorbed relatively well through the skin. Dermal absorption decreases with increasing chain length (i.e. >= C6).
Applicant's summary and conclusion
- Conclusions:
- In general short chained amines (primary and secondary) are absorbed relatively well through the skin. Dermal absorption decreases with increasing chain length (i.e. >= C6).
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