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EC number: 907-605-7 | CAS number: 68815-47-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 1958
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Comparable to guideline with acceptable restrictions (mostly due to limited documentation; nominal determination of the test atmosphere; strongly reduced turnover of the test atmosphere (maximum 20 L/h))
Data source
Referenceopen allclose all
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 958
- Report date:
- 1958
- Reference Type:
- other company data
- Title:
- Unnamed
- Year:
- 2 002
- Report date:
- 2002
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 403 (Acute Inhalation Toxicity)
- Version / remarks:
- adopted 1981, Annex
- Deviations:
- yes
- Remarks:
- determination of the test atmosphere by reweighing of a test substance column
- GLP compliance:
- no
- Test type:
- other: IHT (Inhalation hazard test)
- Limit test:
- yes
Test material
- Reference substance name:
- bis(6-aminohexyl)amine; hexane-1,6-diamine
- EC Number:
- 907-605-7
- Cas Number:
- 68815-47-4
- Molecular formula:
- C6H16N2 (HMD) C12H29N3 (BHT)
- IUPAC Name:
- bis(6-aminohexyl)amine; hexane-1,6-diamine
- Details on test material:
- - Name of test material (as cited in study report): Hexamethylendiamin-Rueckstande
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Mean weight at study initiation: 126 g (animals of both sexes and both trials combined)
ENVIRONMENTAL CONDITIONS
not reported
Administration / exposure
- Route of administration:
- inhalation: vapour
- Type of inhalation exposure:
- whole body
- Vehicle:
- air
- Details on inhalation exposure:
- Rats were exposed for 8 h to a vapour saturated atmosphere.
Vapour was generated by bubbling dry air (no CO2) through the liquid substance column (volume ca. 120 ml) above a fritted glass disc in a glass cylinder. This glass cylinder was placed in an oil bath with a temperature of 50°C. Temperature in the exposure chamber was 20°C.
Due to the increasing viscosity of the test substance during the exposure period, the normally used turnover of 200 L/h dropped down to maximum 20 L/h which was about half of the needed amount of fresh air (36 L/h per 6 animals). - Analytical verification of test atmosphere concentrations:
- no
- Duration of exposure:
- 8 h
- Concentrations:
- 3.1 mg/L nominal
- No. of animals per sex per dose:
- 3 animals of each sex
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 15 days
- Frequency of observations and weighing: Groupwise weighing was done on days 0, 4, 8, 11 and 15. Detailed clinical observations were performed several times at the day of exposure and daily with the exception of weekends and holidays afterwards.
- Necropsy of survivors performed: no
Results and discussion
Effect levels
- Sex:
- female
- Dose descriptor:
- other: IHT
- Effect level:
- 3.1 mg/L air
- Based on:
- test mat.
- Remarks:
- nominal
- Exp. duration:
- 8 h
- Remarks on result:
- other: 0/6 animals died during exposure to the volatile parts of the test item for 8 h
- Mortality:
- 0/6 animals died
- Clinical signs:
- other: After 40 min of exposure eyelid closure and ruffled fur, after 5 h gasping. On the day after application free from symptoms.
- Body weight:
- Constant body weight gain during the observation period.
- Gross pathology:
- not performed.
Applicant's summary and conclusion
- Conclusions:
- Testing for acute toxicity after exposure through inhalation a limit test equivalent to the one set out in OECD TG 403 was performed. None of the six animals (male and female rats) exposed for 8 hours to saturated vapour containing 3.1 mg test item per l air (nominal determination) died during the 14 day observation period. Having these results one could state that under the conditions tested the median lethal dose of the test item is > 3.1 mg/l.
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