Strontium chromate

Acute Toxicity: other routes

Administrative data

Endpoint:

acute toxicity: other routes

Type of information:

migrated information: read-across from supporting substance (structural analogue or surrogate)

Adequacy of study:

weight of evidence

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Read-across from a sparingly water soluble chromate and from a highly water soluble chromate. Not a guideline or GLP study.

Cross-reference

Reason / purpose for cross-reference:

reference to same study

Data source

Reference

Reference Type:

publication

Title:

Toxicokinetics of hexavalent chromium in the rat after intratracheal administration of chromates of different solubilities.

Author:

Bragt, P. C. and E. A. van Dura

Year:

1983

Bibliographic source:

Ann Occup Hyg.27(3): 315-22.

Materials and methods

Principles of method if other than guideline:

kinetics in the rat after a single intratracheal dose of a substance

GLP compliance:

not specified

Test material

Test material information

Constituent 1

Reference substance name:

sodium chromate, zinc chromate, lead chromate

IUPAC Name:

sodium chromate, zinc chromate, lead chromate

Test animals

Species:

rat

Strain:

Wistar

Sex:

male

Details on test animals or test system and environmental conditions:

TEST ANIMALS
- Weight at study initiation: 165-200 g
- Housing: individually in stainless steel metabolic cages
- Diet (e.g. ad libitum): standard pellet diet (Hope Farms, Woerden, the Netherlands)
- Water (e.g. ad libitum): ad libidum

Administration / exposure

Route of administration:

other: intratracheal

Details on exposure:

The animals were anaesthesised during injection.

Doses:

20 ul solution or suspension of either sodium chromate (69 ug Cr), zinc chromate (66 ug Cr) or lead chromate (38 ug Cr) in saline containing 0.4-6.0 uCi 51Cr;

Results and discussion

Any other information on results incl. tables

Zinc chromate caused macroscopically visible haemorrhages and exudation of the lungs within 24 h after its administration, resulting in irregular and halting breathing. These symptoms disappeared on day 6.

Applicant's summary and conclusion

Executive summary:

Bragt and van Dura (1983) studied the kinetics of chromium in the rat after a single intratracheal dose of sodium, zinc or lead⁵¹Cr-chromate. The rats received a 20 μl solution or suspension of either sodium chromate (69 μg Cr), zinc chromate (66 μg Cr) or lead chromate (38 μg Cr). Intratracheal instillation of sparingly water-soluble zinc chromate produced irregular breathing and lung haemorrhage and oedema at 24 hours in male Wistar rats.