Registration Dossier
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EC number: 200-860-9 | CAS number: 75-31-0
Dissociation constant
Administrative data
Link to relevant study record(s)
- Endpoint:
- dissociation constant
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- Study initiation date: 29 June 2009 Study completion date: 19 October 2009
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 112 (Dissociation Constants in Water)
- Version / remarks:
- adopted on 12 May 1981
- Deviations:
- no
- GLP compliance:
- yes
- Dissociating properties:
- yes
- No.:
- #1
- pKa:
- 10.8
- Temp.:
- 23.5 °C
- Remarks on result:
- other: based on two replicate determinations
- Conclusions:
- Dissociation constant (OECD 112): pKa = 10.8 (alkaline functionality; at 23.5 °C)
- Executive summary:
The dissociation constant of the test item was determined in a valid GLP compliant study performed according to OECD guideline no. 112 [adopted on 12 May 1981] with the titration method.
Result:
Dissociation constant (at 23.5 °C): pKa = 10.8 (alkaline functionality).
Reference
Details on replicate determinations:
First run |
Second run |
|
pKa |
10.78 |
10.77 |
pH value of aqueous solution |
11.4 |
11.4 |
Mean value of pKa |
10.8 |
For the plot of a titration curve, see attached figure below.
Description of key information
Dissociation constant (OECD 112): pKa = 10.8 (alkaline functionality; at 23.5 °C)
Key value for chemical safety assessment
- pKa at 20°C:
- 10.8
Additional information
The dissociation constant of the test item was determined in a valid GLP compliant study performed according to OECD guideline no. 112 [adopted on 12 May 1981] with the titration method.
Result:
Dissociation constant (at 23.5 °C): pKa = 10.8 (alkaline functionality).
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