Registration Dossier
Registration Dossier
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EC number: 200-860-9 | CAS number: 75-31-0
Direct observations: clinical cases, poisoning incidents and other
Administrative data
- Endpoint:
- direct observations: clinical cases, poisoning incidents and other
- Type of information:
- other: review
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- abstract
Data source
Referenceopen allclose all
- Reference Type:
- review article or handbook
- Title:
- Unnamed
- Year:
- 1 981
- Report date:
- 1981
- Reference Type:
- review article or handbook
- Title:
- Chemical hazards of the workplace
- Author:
- Proctor NH, Hughes JP
- Year:
- 1 978
- Bibliographic source:
- 2nd. ed., p292, Lippincott, Philadelphia (cited from Beard and Noe 1981, T01289)
Materials and methods
- Study type:
- other: Health report on exposed workers
- Endpoint addressed:
- respiratory irritation
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- no data
- GLP compliance:
- no
Test material
- Reference substance name:
- Isopropylamine
- EC Number:
- 200-860-9
- EC Name:
- Isopropylamine
- Cas Number:
- 75-31-0
- Molecular formula:
- C3H9N
- IUPAC Name:
- propan-2-amine
- Test material form:
- liquid
Constituent 1
Method
- Type of population:
- occupational
- Route of exposure:
- inhalation
- Reason of exposure:
- unintentional, occupational
- Exposure assessment:
- not specified
Results and discussion
- Clinical signs:
- Humans briefly exposed to 10 to 20 ppm of isopropylamine (= 24.6 - 49.2 mg/m3) experienced irritation of the nose and throat.
Workers complained of transient visual disturbances (halos around lights) after exposure to the vapor for 8 h,
probably owing to mild corneal edema, which usually cleared within 3 - 4 h. (Report p. 3154). - Results of examinations:
- Humans briefly exposed to 10 to 20 ppm of isopropylamine (= 24.6 - 49.2 mg/m3) experienced irritation of the nose and throat.
Workers complained of transient visual disturbances (halos around lights) after exposure to the vapor for 8 h,
probably owing to mild corneal edema, which usually cleared within 3 - 4 h. (Report p. 3154).
Applicant's summary and conclusion
- Conclusions:
- Under the conditions of this study, there were first adverse effects in workers (irritation of the nose and throat) briefly exposed to 10-20 ppm (24.6 - 49.2 mg/m3). Exposure to the vapour for 8 h provoked transient visual disturbances (halos around lights), probably owing to mild corneal edema, which usually cleared within 3 - 4 h
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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