Registration Dossier
Registration Dossier
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EC number: 220-099-6 | CAS number: 2627-95-4
Endpoint summary
Administrative data
Description of key information
Additional information
Reliable short-term toxicity tests results are available for freshwater fish (Oncorhynchus mykiss), invertebrates (Daphnia magna) and algae (Pseudokirchneriella subcapitata) for the registration substance. The relevant short-term values are:
Fish: LC50 (96-h): >0.13 mg/l
Daphnia: EC50 (48-h): >0.1 mg/l
Algae: EC50 (72-h): >0.12 mg/l; NOEC: >=0.12 mg/l
A long-term invertebrate (Daphnia magna) toxicity study is available determining a 21 day NOEC value of ≥0.12 mg/l.
The studies with Oncorhynchus mykiss, Daphnia magna and Pseudokirchneriella subcapitata determined no effects at the limit of solubility of the substance.
An activated sludge respiration inhibition 3 hour EC50 value of >1000 mg/l and NOEC value of ≥1000 mg/l (nominal) were determined in a reliable study.
No sediment toxicity data are available with the registration substance. Data have been read across from structural analogues L2 (hexamethyldisiloxane, CAS 107-46-0) and L3 (octamethyltrisiloxane, CAS 107-51-7):
A 28 day NOEC of ≥2.7 mg/kg dry weight has been determined for effects of L2 on reproduction and biomass of Lumbriculus variegatus (≥4.5 mg/kg dry weight, normalised to 5% organic carbon) (Smithers Viscient, 2016).
A 28 day NOEC of 39 mg/kg dry weight has been determined for effects of L3 on emergence and development rate of Chironomus riparius (89 mg/kg dry weight, normalised to 5% organic carbon) (Wildlife International, 2009).
A 28 day NOEC of ≥70 mg/kg dry weight has been determined for the effects of L3 on survival and weight of Hyalella azteca (Smithers Viscient, 2013).
Refer to Section 7.0 and the siloxanes category report (PFA 2017) attached in Section 13 of IUCLID for further discussion of the approach to chemical safety assessment and justification for read across.
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