Registration Dossier
Registration Dossier
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EC number: 238-485-8 | CAS number: 14484-69-6
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
A 96-h LC50 value of 8.9 mg/L in zebra fish is observed, which corresponds to a 96-h LC50 of >4.75 mg/L based on fluoride. The 96-h LC50 of >4.75 mg fluoride/L is used in the assessment.
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Effect concentration:
- 4.75
Additional information
No short-term toxicity test with fish is available for potassium tetrafluoroaluminate. The results from the structural analogue multiconstituent aluminium potassium fluoride are used instead (for details see Reporting Format as attached to the respective IUCLID entry and CSR Appendix B.3). One GLP-compliant OECD 203 guideline study is available for short-term toxicity in zebra fish (Brachydanio rerio) for multiconstituent aluminium potassium fluoride. The test was conducted as a limit test for which the test concentration was based on a previous test with algae (Solvay Pharmaceuticals, 2010a), the concentrations were analytically verified. At the concentration tested (10 mg/L), no mortality and abnormal behaviour was observed. Therefore, a 96-h LC50 value of >10 mg/L was reported (Solvay Pharmaceuticals, 2010a). As the contents of fluoride, expressed as a percentage of the molar weight in both substances are comparable, namely 53.5% for potassium tetrafluoroaluminate and ca. 51% for multiconstituent aluminium potassium fluoride, as a result no safety factor is applied. Instead, the effect concentrations will be corrected for molecular weight.The corrected effect concentration for potassium tetrafluoroaluminate is >8.88 mg/L, which corresponds to an effect concentration of >4.75 mg fluoride/L.
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