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Ecotoxicological information

Short-term toxicity to fish

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Administrative data

Link to relevant study record(s)

Reference
Endpoint:
short-term toxicity to fish
Type of information:
experimental study
Adequacy of study:
key study
Study period:
10 September 1984 - 31 October 1984
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
OECD Guideline 203 (Fish, Acute Toxicity Test)
Deviations:
yes
Remarks:
Holding: in dechlorinated tap water, Test: in artificial water
GLP compliance:
no
Analytical monitoring:
yes
Details on sampling:
at start and each day
Vehicle:
no
Details on test solutions:
Stock solution: 3 g/l
Test organisms (species):
Danio rerio (previous name: Brachydanio rerio)
Details on test organisms:
Test organism: Zebrafish (Brachydanio rerio)
Weight: 0.25 g
Length: 28 mm
Age: >7 weeks
Acclimation: 13 days in dechlorinated tap water
Supplier: West-Aquarium, Bad-Lauterberg, BRD
Test type:
static
Water media type:
freshwater
Limit test:
no
Total exposure duration:
96 h
Hardness:
100 mg/l as CaCO3
Test temperature:
22.9 - 24.0 °C
pH:
7.0 - 8.0
Dissolved oxygen:
6.3 - 8.0 mg/l
Salinity:
no data
Nominal and measured concentrations:
nominal: 17.8, 32, 56, 100, 178 mg/l
measured: 92 - 101 % of nominal
Details on test conditions:
Vessels: 5 liter glass aquaria
Volume: 2.9 liter (3.0 liter minus 2x 0.05 l for analytical control)
Size: 10 fish per concentration and control
Feeding: none
Aeration: slowly aerated
System: Static-System
Duration: 96 h
Lighting: 12 hours light / 12 hours darkness (yellow light TL 16/20 W)
Reference substance (positive control):
no
Duration:
96 h
Dose descriptor:
LC50
Effect conc.:
75 mg/L
Nominal / measured:
meas. (geom. mean)
Conc. based on:
test mat.
Basis for effect:
mortality (fish)
Duration:
96 h
Dose descriptor:
LC0
Effect conc.:
56 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
mortality (fish)
Duration:
96 h
Dose descriptor:
LC100
Effect conc.:
100 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
mortality (fish)
Details on results:
24 h LC50: 75 mg/l
48 h LC50: 75 mg/l
72 h LC50: 75 mg/l
Validity criteria fulfilled:
yes
Conclusions:
The 96 h LC50 of FAT 20306/B to fish (brachydanio rerio) was 75 mg/l (measured).
Executive summary:

A study was performed in accordance with the OECD guideline 203 to determine the acute toxicity of FAT-20306/B on zebra fish. 10 fish per concentration and control were used in the study. At 100 and 178 mg/L concentration group all fishes were died. At other concentration no mortality was found. Based on the test results, the 96 h LC50 based on the geometric mean was 75 mg/l. The 96 h LC0 was 56 mg/l and the 96 h LC100 was 100 mg/L.

Description of key information

A study was performed in accordance with the OECD guideline 203 to determine the acute toxicity of FAT-20306/B on zebra fish. 10 fish per concentration and control were used in the study. At 100 and 178 mg/L concentration group all fishes were died. At other concentration no mortality was found. Based on the test results, the 96 h LC50 based on the geometric mean was 75 mg/l. The 96 h LC0 was 56 mg/l and the 96 h LC100 was 100 mg/L.

Key value for chemical safety assessment

Fresh water fish

Fresh water fish
Effect concentration:
75 mg/L

Additional information