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Environmental fate & pathways

Hydrolysis

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Description of key information

The test substance is hydrolitically stable at pH 7 and 9. At pH 4 the half-life time at 25 °C is calculated to be 3910 hrs. 

Key value for chemical safety assessment

Half-life for hydrolysis:
3 910 h
at the temperature of:
25 °C

Additional information

In a GLP-compliant study according to OECD guideline 111, hydrolysis of the test substance was tested at varying temperatures and as a function of pH (CG, 1991). Based on the results obtained at the various experimental temperatures at a set pH (pH 4, 6 and 9), half-life periods of the test substance at 25 °C were calculated by means of the Arrhenius equation. In a preliminary test it was determined that the test substance is stable towards hydrolyis at 50 °C at pH 7 and pH9 (percentage hydrolysis of <10 % after 5 days incubation). Half-life times at these pH values and 25 °C were calculated to be >1 year. At pH4 and 50 °C the percentage hydrolysis was found to be >10 % after 5 days incubation. Therefore, at this pH additional testing was performed at 60 and 70 °C. Based on the finding at 50, 60 and 70 °C, the half-life time of the test substance at pH 4 and 25 °C was calculated to be 3909.6 hours (~0.45 year). In a GLP-compliant study according to OECD guideline 111, hydrolysis of the test substance was tested at varying temperatures and as a function of pH (CG, 1991). Based on the results obtained at the various experimental temperatures at a set pH (pH 4, 6 and 9), half-life periods of the test substance at 25 °C were calculated by means of the Arrhenius equation. In a preliminary test it was determined that the test substance is stable towards hydrolyis at 50 °C at pH 7 and pH9 (percentage hydrolysis of <10 % after 5 days incubation). Half-life times at these pH values and 25 °C were calculated to be >1 year. At pH4 and 50 °C the percentage hydrolysis was found to be >10 % after 5 days incubation. Therefore, at this pH additional testing was performed at 60 and 70 °C. Based on the finding at 50, 60 and 70 °C, the half-life time of the test substance at pH 4 and 25 °C was calculated to be 3909.6 hours (~0.45 year).