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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: dermal

Currently viewing:

Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
weight of evidence
Study period:
No data
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
documentation insufficient for assessment
Remarks:
.

Data source

Reference
Reference Type:
other company data
Title:
Unnamed
Year:
1976
Report date:
1976

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: no data
Deviations:
not applicable
Principles of method if other than guideline:
Applied as a 40 % aqueous solution.
GLP compliance:
no
Remarks:
Study pre-dates GLP
Test type:
other: no data

Test material

Constituent 1
Chemical structure
Reference substance name:
Tripotassium orthophosphate
EC Number:
231-907-1
EC Name:
Tripotassium orthophosphate
Cas Number:
7778-53-2
Molecular formula:
H3O4P.3K
IUPAC Name:
tripotassium orthophosphate
Test material form:
other: aqueous solution of test material
Details on test material:
- Name of test material: Tripotassium phosphate
- Lot/batch No.: 7354-500-52-008

Test animals

Species:
rabbit
Strain:
New Zealand White
Sex:
male/female
Details on test animals or test system and environmental conditions:
No data

Administration / exposure

Type of coverage:
not specified
Vehicle:
water
Details on dermal exposure:
TEST MATERIAL
- Concentration: 40 % aqueous solution
Duration of exposure:
24 h
Doses:
5010 and 7940 mg/kg
No. of animals per sex per dose:
1 male only at 5010 mg/kg dose; 1 male and 1 female at 7940 mg/kg dose.
Control animals:
not specified
Details on study design:
- Duration of observation period following administration: 14 days
- Other examinations performed: Clinical signs
Statistics:
No data

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LD50
Effect level:
> 7 940 mg/kg bw
Remarks on result:
other: 40 % aqueous solution
Mortality:
There were no mortalities.
Clinical signs:
other: Reduced appetite and activity (2 to 3 days).
Gross pathology:
Viscera appeared normal in survivors.
Other findings:
No data

Any other information on results incl. tables

Table 1. Applied as a 40 % aqueous solution

Dosage

(mg/kg)

Initial weight

Mortalities/dosed

Male

Female

Male

Female

Combined

5010

2.1

-

0 / 1

-

0 / 1

7940

2.3

1.9

0 / 1

0 / 1

0 / 2

Applicant's summary and conclusion

Interpretation of results:
GHS criteria not met
Conclusions:
The LD50 of tripotassium phosphate when applied dermally as a 40 % aqueous solution was > 7940 mg/kg.

This study is considered to fulfil the data requirements as defined under Annex XI, section 1.2. of Regulation (EC) N. 1907/2006 (REACH) as part of a weight of evidence approach and no further testing is considered necessary.