Registration Dossier
Registration Dossier
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EC number: 931-274-8 | CAS number: 28182-81-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Endpoint summary
Administrative data
Key value for chemical safety assessment
Additional information
The substance showed no mutagenic properties in fully reliable bacterial reverse mutation assays according to OECD TG 471, in mammalian cell gene mutation assays according to OECD TG 476, and in in vitro chromosome aberration assays according to OECD TG 473.
Additionally available is a Mammalian Bone Marrow Micronucleus Test similar to OECD TG 474. In this study 5 mice/sex were treated orally with a single limit dose of 5000 mg/kg prior to bone marrow sampling after 24, 48 and 72 hours. No increase in the frequencies of micronuclei were observed after exposure, therefore it was concluded that the test substance was devoid of mutagenic activity. In this study no substance-related toxic symptoms were observed and also no appreciable suppression of marrow proliferation, as indicated by shifts in the PCE/NCE ratios. The slightly reduced number of PCE recorded in the 48 h samples was taken to indicate that the test compound had reached the target organ. Thus, under the experimental conditions chosen here, no indications were found for a genotoxic potential in vivo.
Justification for selection of genetic toxicity endpoint
No study selected since none of the available studies (several in vitro, one in vivo) conclude a genotoxic potential for the substance.
Endpoint Conclusion: No adverse effect observed (negative)
Justification for classification or non-classification
According to Regulation (EC) No 1272/2008, Annex I, no classification is warranted for genetic toxicity.
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