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EC number: 230-785-7 | CAS number: 7320-34-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- Testing was conducted between 02 October 2009 and 04 February 2010.
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Remarks:
- Date of inspection: 15 September 2009 Date of Signature: 26 November 2009
- Type of method:
- flask method
- Remarks:
- The determination was carried out using the flask method, Method A6 Water Solubility of Commission Regulation (EC) No 440/2008 of 30 May 2008.
- Water solubility:
- >= 67.2 - <= 69.9 other: % w/w
- Temp.:
- 20 °C
- pH:
- 10.6
- Details on results:
- Please see section Remarks on results including tables and figures.
- Conclusions:
- Interpretation of results (migrated information): very soluble (> 10000 mg/L)
The water solubility of the test material has been determined to be in the range 67.2 to 69.9 % w/w at 20.0 ± 0.5°C.
The effect of temperature over the range 10 to 30°C has been considered not to have had a significant influence on the observed solubility of the test material.
Additionally, an assessment of the solubility of the test material over the environmentally relevant pH range of 4 to 9 gave observed solubilities and final solution pH’s similar to those obtained using unbuffered water. Thus, it can be anticipated that the water solubility of the test material over the pH range 4 to 9 would be constant, essentially due to the low buffering activities seen in the environment.
This study is conducted according to an appropriate method and under the conditions of GLP and therefore the study is considered to be acceptable and to adequately satisfy the regulatory requirement as a key study for this endpoint. - Executive summary:
Method
The determination was carried out by visual assessment using a flask method, based on Method A6 Water Solubility of Commission Regulation (EC) No 440/2008 of 30 May 2008.
Conclusion
The water solubility of the test material has been determined to be in the range 67.2 to 69.9 % w/wat 20.0±0.5°C.
The effect of temperature over the range 10 to 30°C has been considered not to have had a significant influence on the observed solubility of the test material.
Additionally, an assessment of the solubility of the test material over the environmentally relevant pH range of 4 to 9 gave observed solubilities and final solution pH’s similar to those obtained using unbuffered water. Thus, it can be anticipated that the water solubility of the test material over the pH range 4 to 9 would be constant, essentially due to the low buffering activities seen in the environment.
Reference
Results
Preliminary test
The sample concentrations, observations and solution pH are shown in the following table:
Sample |
Concentration |
Observations |
Solution pH |
1 |
10.1 |
Clear colourless solution, test material completely dissolved. |
10.7 |
2 |
25.0 |
Clear colourless solution, test material completely dissolved. |
10.8 |
3 |
40.0 |
Clear colourless solution, test material completely dissolved. |
10.7 |
4 |
60.0 |
Clear colourless solution, test material completely dissolved. |
10.9 |
5 |
74.9 |
Test material not dissolved fully; excess in solution. |
* |
6 |
65.0 |
Slightly viscous, clear colourless solution, no excess undissolved test material. |
12.2 |
7 |
69.9 |
Two-phase system, comprising a slightly viscous, clear colourless liquid and white powder, i.e. excess undissolved test material. |
* |
Preliminary results: Greater than 65.0 % w/w but less than 69.9 % w/w.
*unable to record due to the physical state of the sample
Definitive test
The sample concentrations, observations and solution pH are shown in the following tables:
Sample |
Concentration |
Observations |
Solution pH |
8 |
65.5 |
Test material fully dissolved. |
10.5 |
9 |
67.0 |
Test material not fully dissolved. |
* |
10 |
69.8 |
Test material not fully dissolved. |
* |
11 |
67.2 |
Test material fully dissolved. |
10.6 |
12 |
64.2 |
Test material fully dissolved. |
10.8 |
13 |
67.2 |
Test material fully dissolved. |
10.9 |
14 |
69.6 |
Test material not fully dissolved. |
* |
15 |
64.8 |
Test material fully dissolved. |
10.8 |
16 |
64.6 |
Test material fully dissolved. |
10.9 |
Overall results: 30°C: In the
range 65.5 to 67.0 % w/w
20°C: In the range 67.2 to 69.9 % w/w
10°C: In the range 67.2 to 69.6 % w/w
*unable to record due to the physical state of the sample
Description of key information
The water solubility of the test material has been determined to be in the range 67.2 to 69.9 % w/w at 20.0 ± 0.5°C.
Key value for chemical safety assessment
- Water solubility:
- 10 000 mg/L
- at the temperature of:
- 20 °C
Additional information
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