Registration Dossier
Registration Dossier
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EC number: 201-279-3 | CAS number: 80-43-3
Genetic toxicity: in vivo
Administrative data
- Endpoint:
- in vivo mammalian cell study: DNA damage and/or repair
- Remarks:
- Type of genotoxicity: DNA damage and/or repair
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Study was not performed according to guideline standards, without detailed documentation of results (just one figure presented)
Data source
Reference
- Reference Type:
- publication
- Title:
- Characterization of the tumor-promoting activity of m-chloroperoxybenzoic acid in SENCAR mouse skin and its inhibition by gallotannin, oligomeric proanthocyanidin, and their monomeric units
- Author:
- Chen G, Perchellet EM, Gao XM, Johnson FK, Davis AW, Newell SW, Hemingway RW, Bottari V, Perchellet JP
- Year:
- 1 996
- Bibliographic source:
- Int. J. Oncology 8: 197-206
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- 16 h after two topical applications of DCP within 72 h DNA synthesis was measured by rate of incorporation of [methyl-3H]-thymidine
- GLP compliance:
- no
- Type of assay:
- unscheduled DNA synthesis
Test material
- Reference substance name:
- Bis(α,α-dimethylbenzyl) peroxide
- EC Number:
- 201-279-3
- EC Name:
- Bis(α,α-dimethylbenzyl) peroxide
- Cas Number:
- 80-43-3
- Molecular formula:
- C18H22O2
- IUPAC Name:
- 1,1'-(dioxydipropane-2,2-diyl)dibenzene
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- Sencar
- Sex:
- female
- Details on test animals or test system and environmental conditions:
- 5 weeks old,
from Harlan Sprague Dawly Inc., Indianapolis, IN
Administration / exposure
- Route of administration:
- dermal
- Vehicle:
- Acetone
- Details on exposure:
- substance was dissolve in acetone and applied on the back
- Frequency of treatment:
- twice within 72 h
- Post exposure period:
- 16 h
Doses / concentrations
- Remarks:
- Doses / Concentrations:
2.5 mg
Basis:
nominal conc.
- No. of animals per sex per dose:
- 4
- Control animals:
- yes, concurrent vehicle
Results and discussion
Any other information on results incl. tables
No increase in DNA synthesis was observed after two topical applications of 2.5 mg dicumylperoxide.
Control showed a DNA synthesis of approx. 50 cpm/µg DNA. After application of dicumylperoxide a value of 45 cpm/µg DNA was obtained (all values read from figure).
Applicant's summary and conclusion
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