Registration Dossier
Registration Dossier
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EC number: 204-634-0 | CAS number: 123-54-6
Bioaccumulation: aquatic / sediment
Administrative data
- Endpoint:
- bioaccumulation: aquatic / sediment
- Type of information:
- calculation (if not (Q)SAR)
- Remarks:
- Migrated phrase: estimated by calculation
- Adequacy of study:
- supporting study
- Study period:
- 2000
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Bioaccumulation judged by accepted calculation method.
Data source
Reference
- Reference Type:
- other: calculation
- Title:
- Unnamed
- Year:
- 2 000
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: calculated by EPIWIN
- Deviations:
- no
- Principles of method if other than guideline:
- Method: other: calculated
- GLP compliance:
- no
Test material
- Reference substance name:
- Pentane-2,4-dione
- EC Number:
- 204-634-0
- EC Name:
- Pentane-2,4-dione
- Cas Number:
- 123-54-6
- Molecular formula:
- C5H8O2
- IUPAC Name:
- pentane-2,4-dione
- Details on test material:
- calculation
Constituent 1
- Specific details on test material used for the study:
- Details on properties of test surrogate or analogue material (migrated information):
calculation - Radiolabelling:
- no
Test solutions
- Vehicle:
- no
- Details on preparation of test solutions, spiked fish food or sediment:
- not applicable
Study design
- Test type:
- other: not applicable
Test conditions
- Hardness:
- not applicable
- Test temperature:
- not applicable
- pH:
- not applicable
- Dissolved oxygen:
- not applicable
- TOC:
- not applicable
- Salinity:
- not applicable
- Details on test conditions:
- not applicable
- Nominal and measured concentrations:
- not applicable
- Reference substance (positive control):
- not required
- Details on estimation of bioconcentration:
- Log BCF was calculated with the program EPIWIN. For nonionic substances with a log Kow< 1.0 this program specifies a log BCF = 0.5., which is in accordance with recommendations of the US EPA.
Results and discussion
Bioaccumulation factor
- Type:
- BCF
- Value:
- 3.16
- Basis:
- not specified
- Calculation basis:
- steady state
- Details on kinetic parameters:
- not applicable
- Metabolites:
- not applicable
- Results with reference substance (positive control):
- not applicable
- Details on results:
- LogKow used: 0.40 log BCF: 0.5
- Reported statistics:
- not applicable
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Conclusions:
- No risk of bioaccumulation for this substance.
- Executive summary:
Taking into consideration the measured octanol/water partition coefficients of 0.34 and 0.40 no
potential for bioaccumulation/bioconcentration and geoaccumulation can be identified. Assuming a
log Kow of 0.40 a calculated bioconcentration factor of 3.162 (log BCF = 0.5) results there from
(EPIWIN 2000).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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