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Key value for chemical safety assessment

Additional information

According to the key study, the material was examined for mutagenic activity in two histidine-dependent auxotrophs of Salmonella typhimurium, strains TA98 and TA100, using por-plate assays. the studies, which were conducted in the presence and absence of an activating system derived from rat liver (S-9), employed a range of levels of the substance from 0.5 to 50µg per plate, selected following a preliminary toxicity test in strain TA98. The test included solvent (ethanol) controls with and without S-9 mix. It was concluded that the substance did not exhibit any mutagenic activity under the conditions of test.


Short description of key information:
Full details of these endpoints are provided in the IUCLID dossier and they are considered reliable.

Results are presented below:

It was concluded that the substance did not exhibit any mutagenic activity under the conditions of test.

Endpoint Conclusion: No adverse effect observed (negative)

Justification for classification or non-classification