Registration Dossier
Registration Dossier
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EC number: 203-347-8 | CAS number: 105-95-3
Endpoint summary
Administrative data
Description of key information
Additional information
Based on the analytical problems observed in the experimental ecotoxicological studies, a weight of evidence approach with QSAR estimations has been considered more appropriate to assess the aquatic toxicity of the substance than basing the results uniquely upon the exisiting aquatic dataset. Further investigation is ongoing on this difficult substance in order to determine whether instability or analytical issues accounted for the loss observed in older test samples.
To obtain reliable endpoint values, geometric means between the experimental results (based on initial measured concentrations) and the QSAR estimations (ECOSAR v1.11 QSAR model available from the U.S. EPA) were determined for three trophic levels: Algae, Invertebrates and Fish. The results are summarised in the table below.
Organism |
EC50/LC50 |
NOEC |
Flag / reliability |
Reference in IUCLID / comments |
Acute |
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Aquatic algae |
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Not relevant |
3.39 mg/L |
2.10 mg/L |
Not relevant |
Weight of evidence approach |
Aquatic invertebrates |
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Not relevant |
4.65 mg/L |
- |
Not relevant |
Weight of evidence approach |
Fish |
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Not relevant |
1.87 mg/L |
- |
Not relevant |
Weight of evidence approach |
Micro-organisms |
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activated sewage sludge |
30min: 12400 mg/L |
- |
K/2 |
Toxicity to microorganisms, Caspers, 1996, RS, K |
Among all data available, fish seems to be the most sensitive species in acute exposure with an estimated 96h-LC50 at 1.87 mg/L.
No valid chronic studies are available. The choice to perform long-term studies will be defined after further investigation on this difficult substance.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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