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Toxicological information

Acute Toxicity: inhalation

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Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
disregarded due to major methodological deficiencies
Study period:
1975
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: see 'Remark'
Remarks:
The study was performed before OECD test guidelines and GLP were established. The documentation is according to the best practice at the time the study was performed. However, some critical details of the test protocol and the results are not available. This study is not comparable with an acute inhalation toxicity study according to OECD test guideline no. 403. The study determined the effects of inhaling a saturated atmosphere at room temperature. Since the vapour pressure of the test substance is extremely low, there was virtually no exposure.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1976
Report date:
1976

Materials and methods

Test guideline
Qualifier:
no guideline available
Principles of method if other than guideline:
BASF Inhalation Hazard Test
GLP compliance:
no
Remarks:
Pre-GLP
Limit test:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
2-Oxetanone, 3-C12-16-alkyl-4-C13-17-alkylidene derivs.
EC Number:
284-932-5
EC Name:
2-Oxetanone, 3-C12-16-alkyl-4-C13-17-alkylidene derivs.
Cas Number:
84989-41-3
Molecular formula:
C32H60O2 / C34H64O2 / C36H68O2
IUPAC Name:
(4E)-4-(C13-C17)alkylidene-3-(C12-C16)alkyloxetan-2-one
Details on test material:
Test substance: other TS: Stearyldiketen TV 194/37

An AKD manufactured using a stearic acid rich blend of palmitic and stearic fatty acids.

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified

Administration / exposure

Route of administration:
inhalation: vapour
Type of inhalation exposure:
not specified
Vehicle:
other: unchanged (no vehicle)
Analytical verification of test atmosphere concentrations:
no
Duration of exposure:
8 h
No. of animals per sex per dose:
12

Results and discussion

Effect levels
Remarks on result:
other: No mortality was observed when 12 rats were exposed for 8 hours to an atmosphere that has been saturated at 20 degrees celcius  with the volatile part of the compound.
Clinical signs:
other:

Any other information on results incl. tables

Test Conditions: This test was performed according to principle described  in OECD TG 403. It demonstrates the toxicity of an atmosphersaturated  with 

vapours of the volatile components of the test substance. Groups of  three young adult rats were sequentially exposed to the vapours,   generated by bubbling 200L/h air through a 5 cm column of the test  substance. No analytical determination of the atmosphere concentration  was performed. 

However, very little AKD vapour is expected to be present  in an atmosphere saturated with AKD vapour, since the vapour pressure of  AKD is extremely low 

with an estimated 3x10-6 hPa at 40o Celsius. The  study allows for an estimate of the length of time required to cause  severe toxicity by exposure to a 

saturated atmosphere. The study does not  allow any estimation of the inhalation toxicity of AKD dusts.

Applicant's summary and conclusion

Interpretation of results:
other: Due to limited reporting interpretation is not possible.