Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 500-035-6 | CAS number: 25214-63-5 (>1 <8.5 mol PO)
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: 1a Guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 995
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- Ethylenediamine, propoxylated
- EC Number:
- 500-035-6
- EC Name:
- Ethylenediamine, propoxylated
- Cas Number:
- 25214-63-5
- Molecular formula:
- (C3H6O)n (C3H60)n (C3H6O)n(C3H6O)n C2H8N2 sum of n: >1 - 8.5
- IUPAC Name:
- Ethylenediamine, propoxylated
- Details on test material:
- Ethylenediamine, propoxylated
MW 280
clear, colourless, viscous liquid
purity not reported
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ORGANISMS: Wistar-rats (Hsd/Win:WU)
- Source: Harlan-Winkelmann GmbH, Borchen, Germany
- Age: 6 - 9 weeks
- Weight at study initiation: males 241 g, females 167 g
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- other: polyethylene glycol 400
- Details on oral exposure:
- ADMINISTRATION:
- Administration route: gavage, fasted animals
- Administrationvolume: 10 ml/kg bw
- Group size: 5 /dose/sex
- Post dose observation period: 14 days - Doses:
- 2000 mg/kg bw
- No. of animals per sex per dose:
- 5 animals/dose/sex
- Details on study design:
- EXAMINATIONS: Any deaths and overt signs of toxicity were recorded repeated times on day of dosing and daily for 14 days. Bodyweights were recorded on the day of dosing and on days 7 and 14. At the end of the study all animals were subject to gross necropsy, macroscopic abnormalities were recorded, no tissues were retained.
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Mortality:
- MORTALITY: No animals died.
- Clinical signs:
- other: CLINICAL SIGNS: There were no signs of systemic toxicity.
- Gross pathology:
- NECROPSY FINDINGS: No findings
Applicant's summary and conclusion
- Conclusions:
- The rat oral LD50 for the test-substance is >2000 mg/kg bw. and no adverse effects were observed at this dose level.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
