Registration Dossier
Registration Dossier
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EC number: 202-951-9 | CAS number: 101-54-2
Repeated dose toxicity: other routes
Administrative data
- Endpoint:
- sub-chronic toxicity: other route
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: limited documented publication and limited study design (unphysiological route of administration)
Data source
Reference
- Reference Type:
- publication
- Title:
- P-aminodiphenylamine induced biochemical changes in sex organs of male albino rats
- Author:
- Singh, R.L. et al
- Year:
- 1 992
- Bibliographic source:
- Indian Journal of Experimental Biology 30, 110-113
Materials and methods
- Principles of method if other than guideline:
- other: subchronic
- GLP compliance:
- not specified
Test material
- Reference substance name:
- N-(4-aminophenyl)aniline
- EC Number:
- 202-951-9
- EC Name:
- N-(4-aminophenyl)aniline
- Cas Number:
- 101-54-2
- Molecular formula:
- C12H12N2
- IUPAC Name:
- N1-phenylbenzene-1,4-diamine
- Details on test material:
- no data
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male
Administration / exposure
- Route of administration:
- intraperitoneal
- Duration of treatment / exposure:
- 180 d
- Frequency of treatment:
- daily
Doses / concentrations
- Remarks:
- Doses / Concentrations:
42.5 mg/kg bw
- No. of animals per sex per dose:
- 30
- Control animals:
- yes, concurrent vehicle
Results and discussion
Target system / organ toxicity
- Critical effects observed:
- not specified
Any other information on results incl. tables
Food intake and body weight gain: no effects
Organ weights: testis, accessory sex organs: comparable to control
Biochemical parameters:
LDH and hyaluronidase activity decreased
Testicular lactic: decreased
protein, total, free esterified choloesterol: no effects
Histopathology: adverse effects in testis (e.g. degeneration of seminiferous tubules)
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
