Registration Dossier
Registration Dossier
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EC number: 201-114-5 | CAS number: 78-40-0
Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: insufficient documented
Data source
Reference
- Reference Type:
- publication
- Title:
- The pharmacologic action of some alcoholic phosphoric esters
- Author:
- Smith MI
- Year:
- 1 936
- Bibliographic source:
- National Institute of Health bulletin, vol. 165, 11-29 (1936)
Materials and methods
- Principles of method if other than guideline:
- Triethyl phosphate was examined in albino rats of about 100 to 150 grams. The intraperitoneal route of injection was used.
- GLP compliance:
- no
Test material
- Reference substance name:
- Triethyl phosphate
- EC Number:
- 201-114-5
- EC Name:
- Triethyl phosphate
- Cas Number:
- 78-40-0
- Molecular formula:
- C6H15O4P
- IUPAC Name:
- triethyl phosphate
- Details on test material:
- no data
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Route of administration:
- intraperitoneal
- Vehicle:
- not specified
- Doses:
- no data
- No. of animals per sex per dose:
- no data
- Control animals:
- not specified
Results and discussion
Effect levels
- Dose descriptor:
- LD50
- Effect level:
- 950 mg/kg bw
Any other information on results incl. tables
Systemic effects: incoordination, muscular weakness, respiratory and and circulatory paralysis and death in a few minutes
Applicant's summary and conclusion
- Executive summary:
LD50 (rat) = 950 mg/kg bw.
Systemic effects: incoordination, muscular weakness, respiratory and and circulatory paralysis and death in a few minutes
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