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EC number: 240-245-2 | CAS number: 16090-02-1
Distribution of radioactivity in male rabbits three days after topical application of 20 µg 14C-test substance / cm²
n.d. = not determined, n.m. = no material obtained
Blood levels of radioactivity in male rabbits after topical application of 14C-test substance/ cm2; values are given in percent of dose, present in the total blood volume, assuming that blodd represents 5 % of the body weight.
LQ: Limit of quantitation: 0.016 %, equivalent to 2.7 ppb
LD: Limit of detection: 0.006 %, equivalent to 0.9 ppb
The percutaneous absorption was tested following procedures similar to those outlined into the OECD guideline 427. Test material was applied to 3 male Himalayan rabbits, evenly distributed using a syringe fitted with a blunted hypodermic needle.
Test substance is not absorbed by rabbits after topical application as tested in this study.
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