Registration Dossier
Registration Dossier
Diss Factsheets
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EC number: 617-779-3 | CAS number: 85940-94-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Endpoint summary
Administrative data
Description of key information
Additional information
Justification for the non-equivalence of the test material to the submission substance identity
HDI trimer MEKO blocked is always produced and marketed as dissolved in solvent. Thus, the substance is reasonably expected to be handled and used in a form of a mixture of the registered substance in the solvent. The environment is anticipated to be exposed rather to the mixture than to the pure substance. Thus, the testing strategy was designed to take this route of exposure into account and it has been concluded that testing the mixture was more relevant than testing the registered substance as such.
To conclude, environmental fate studies were performed on the mixture and as a consequence for endpoint study records, the test material is not ticked when requesting if equivalent to submission substance identity.
Summary of available data
Considering the type of substance (UVCB) and according to manufactures experience, the registered substance is to be considered as difficult to analyse. In addition, the test material (being the mixture of the registered substance in the solvent) exhibits low water solubility (less than 100 mg/L). The test material has to be considered as a difficult mixture to be tested particularly for achieving exposure concentration and preparing representative media.
In a hydrolysis study (OECD TG 111), a half-life of 139 d for pH 7 at 25 °C in water was calculated for the registered substance (HDI Trimer MEKO-blocked) from experimental data obtained at 50, 65 and 80°C. Considering the nature of the substance (UVCB), it was not possible to identify the hydrolysis product. Therefore, the registered substance is to be considered as stable to hydrolysis based on the available half-life.
In a standard screening biodegradation test (manometric respirometry method), the percentage of biodegradation of test material was determined at 3, 4, 7 and 9% based on BOD after 6, 12, 20 and 28 days of exposure, respectively. Thus, the test material does not meet the readily biodegradable criterion. Therefore, the registered substance has to be considered as not readily biodegradable.
The adsorption coefficient (Koc) of the registered substance (HDI Trimer MEKO-blocked) was determined by High Performance Liquid Chromatography (HPLC). The experiment was conducted in accordance with the OECD Guideline 121 and in compliance with the OECD-GLP standard. A key value of log Koc values has been determined to 3.0. Therefore the registered substance is to be considered of low mobility.
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