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EC number: 617-779-3 | CAS number: 85940-94-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Reliable without restriction, GLP guideline study
Cross-referenceopen allclose all
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to other study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 010
- Report date:
- 2010
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- Desmodur BL 3175 SN
- IUPAC Name:
- Desmodur BL 3175 SN
- Details on test material:
- - Name of test material (as cited in study report): HDI Trimer MEKO-blocked, approx. 75% in solvent naphta 100; DESMODUR BL 3175 SN
- Physical state: colorless liquid
- Analytical purity:
- Composition of test material, percentage of components:
- Isomers composition:
- Purity test date:
- Lot/batch No.: LDT7090027
- Expiration date of the lot/batch: 2010-06-16
- Stability under test conditions:
- Storage condition of test material: room temperature
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Harlan, GmbH
- Age at study initiation: 9-13 weeks
- Weight at study initiation: male: 272-286g; female: 233-255g
- Fasting period before study: no fasting period
- Housing: caged individuallyin polycarbonate cageson low dust wood granulate bedding
- Diet (e.g. ad libitum): standard diet "Provimi kliba 3883 PM S15 Maus/Ratte haltung, Kaiseraugst Switzerland
- Water (e.g. ad libitum): ad libitum
- Acclimation period: 5 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22 +/- 2°C
- Humidity (%): 55 +/- 5°C
- Air changes (per hr): approx. 10 changes per hour
- Photoperiod (hrs dark / hrs light): 12 hours rythm
IN-LIFE DATES: From: To: No data
Administration / exposure
- Type of coverage:
- semiocclusive
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- TEST SITE
- Area of exposure: back and flanks
- % coverage: approx 10% of the body surface area
- Type of wrap if used: a gauze-layer (6.0 cm * 5.0 cm) of a Cutiplast* steril coeated with air-tight Leukoflex*
REMOVAL OF TEST SUBSTANCE
- Washing (if done): the are was rinsed with tepid water using soap and gently aptting the area dry
- Time after start of exposure: after appro. 24 hours
TEST MATERIAL
- Amount(s) applied (volume or weight with unit): males: 18.1-19.1 mg/cm2; females: 15.5-17.0 mg/cm2
- Concentration (if solution):
VEHICLE: no vehicle
- Amount(s) applied (volume or weight with unit):
- Concentration (if solution):
- Lot/batch no. (if required):
- Purity: - Duration of exposure:
- 24 hours
- Doses:
- 2667 mg/kg bw of DESMODUR BL 3175 SN.
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing:
Clinical observations and mortality: several times on the day of application and at least once a day during observation period
Weight:
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight,organ weights, histopathology - Statistics:
- No data
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 667 mg/kg bw
- Mortality:
- No mortality
- Clinical signs:
- other: No clinical signs observed in male animals. Partial reddening, encrustration and formation of scale of the treatment area were observed in females.
- Gross pathology:
- No particular findings.
- Other findings:
- No data
Any other information on results incl. tables
Dose (mg/kg bw) |
Toxicological results* |
Occurrence of signs |
Time of death |
Mortality (%) |
Male 2000** |
0 / 0 / 5 |
- |
- |
0 |
Female 2000** |
0 / 5 / 5 |
2d – 13d |
- |
0 |
*number of animals which died spontaneously and/or were sacrificed in moribund state / number of animals with signs of toxicity / total number of animals used per groups used per group ** expressed as HDI Trimer MEKO blocked |
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Under the test conditions, DESMODUR BL 3175 SN (75% HDI Trimer MEKO blocked in 25% solvent naphta 100) is not classified for acute
dermal toxicity according to the criteria of the CLP regulation (EC) N°(1272/2008) and the Annex VI to the Directive 67/548/EEC. - Executive summary:
In an acute dermal toxicity study, performed according to OECD 402, in compliance with GLP, 5 rats Wistar by sex were applied with DEMSODUR BL 3175 SN (75% HDI Trimer MEKO blocked in 25% solvent naphta 100) at a concentration of 2667 mg/kg bw.
No mortality, no clinical signs in male, no effect on body weight have been observed. Artial reddening, encrustration and formation of scale of the treatment area were observed in females.
LD50>2667 mg/kg bw .
DESMODUR BL 3175 SN is not classified for acute dermal toxicity according to the criteria of hte CLP regulation (EC) N°(1272/2008) and the Annex VI to the Directive 67/548/EEC.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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