Registration Dossier
Registration Dossier
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EC number: 248-145-0 | CAS number: 26966-75-6
Sensitisation data (human)
Administrative data
- Endpoint:
- sensitisation data (humans)
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Published paper with reasonable details.
Data source
Reference
- Reference Type:
- publication
- Title:
- Dermatitis from quinazoline oxide
- Author:
- Rebandel P & Rudzki E
- Year:
- 1 986
- Bibliographic source:
- Contact Derm. 15 (2): 63-5
Materials and methods
- Study type:
- other: Cohort of sensitised workers
- Principles of method if other than guideline:
- Over 6 years workers reporting with dermatitis were patch tested for a specific allergen, and to other possible contactants, of which one was o-toluenediamine
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 3(or 4)-methylbenzene-1,2-diamine
- EC Number:
- 248-145-0
- EC Name:
- 3(or 4)-methylbenzene-1,2-diamine
- Cas Number:
- 26966-75-6
- Molecular formula:
- C7H10N2
- IUPAC Name:
- 3(or 4)-methylbenzene-1,2-diamine
Constituent 1
Method
- Ethical approval:
- not specified
- Subjects:
- 51 pharmaceutical workers reporting with dermatitis in 1979 through 1985.
- Controls:
- 44 dermatitis patients not in the pharmaceutical industry
- Route of administration:
- dermal
- Details on study design:
- O-TDA was administered as one of a series of contactants to 29 patients with dermatitis that also were positive reatants to quinazolone oxide.
Results and discussion
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
