Registration Dossier
Registration Dossier
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EC number: 248-145-0 | CAS number: 26966-75-6
Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- other: Publication with insufficient details, inadequate observation time and various deficiencies.
Data source
Reference
- Reference Type:
- publication
- Title:
- Effect of 3,4-toluenediamine on output from in situ rat Brunner's glands pouches(38941)
- Author:
- Perkins WE & Green TJ
- Year:
- 1 975
- Bibliographic source:
- Proc.Soc.Exp.Biol.Med. 149: 991-4
Materials and methods
- Principles of method if other than guideline:
- Eight different dose levels were administered by subcutaneous injection to rats. Animals were killed after 24 hours, but mortality reported.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 3(or 4)-methylbenzene-1,2-diamine
- EC Number:
- 248-145-0
- EC Name:
- 3(or 4)-methylbenzene-1,2-diamine
- Cas Number:
- 26966-75-6
- Molecular formula:
- C7H10N2
- IUPAC Name:
- 3(or 4)-methylbenzene-1,2-diamine
- Details on test material:
- 3,4-toluenediamine, 97% pure.
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- female
- Details on test animals or test system and environmental conditions:
- Rats of 200 - 300 g BW
Administration / exposure
- Route of administration:
- subcutaneous
- Vehicle:
- ethanol
- Doses:
- 62.5, 125, 250, 300, 350, 400, 450, 500 mg/kg.
- No. of animals per sex per dose:
- 7 to 20
- Control animals:
- not specified
- Details on study design:
- Animals killed after 24 hours. Study aim was investigation of effect on GI tract secretions
Results and discussion
Any other information on results incl. tables
At doses up to 300 mg /kg there was no mortality.
Dose, mg/kg |
Mortality % |
350 |
5 |
400 |
30 |
450 |
50 |
500 |
94 |
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
