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EC number: 201-236-9 | CAS number: 79-94-7
Table: description of dermal effects observed in rabbits exposed to TBBPA
Short –term, not specified
1 to 3 days
TBBPA was administered to the backs of New Zealand White rabbits,at dosage levels of 100, 500 and 2500 mg/kg/day, 5 days a week, for 3 weeks. Four male and four females rabbits were used at each dosage level and also in a control group. The control rabbits were administered 1.5 ml/kg of 0.9% physiological saline on the same regimen as treated rabbits. The compound was mixed with 0.9% physiological saline to form a paste which was applied. The rabbits were observed daily for signs of overt toxicity, dermal irritation, moribundity and mortality . Body weights were recorded weekly. Hematologic and biochemical studies and urinalyses were conducted during the pretest period and at 3 weeks of study. There was no mortality and no sign of overt toxicity or unusual behavior for the rabbits in any group.
The application of TBBA
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