Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
biochemical or cellular interactions
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
study well documented, meets generally accepted scientific principles, acceptable for assessment

Data source

Reference
Reference Type:
publication
Title:
A calorimetric study of the interaction of synthetic phospholipid liposomes with vinyl monomers, acrylates and methacrylates.
Author:
Fujisawa S, Kadoma Y, Masuhara E
Year:
1984
Bibliographic source:
J. of Biomed. Mater. Res. 18(9): 1105-1114

Materials and methods

Principles of method if other than guideline:
Phospholipid liposomes are often employed as a model system in order to study the interaction of drugs with biological membranes; the molecular mechanism of the interaction of various acrylates and methacrylates with liposomes was investigated by the application of differential scanning calorimetry, and the transition properties induced by monomers in biological systems were monitored.
Type of method:
in vitro

Test material

Constituent 1
Chemical structure
Reference substance name:
2-ethylhexyl methacrylate
EC Number:
211-708-6
EC Name:
2-ethylhexyl methacrylate
Cas Number:
688-84-6
Molecular formula:
C12H22O2
IUPAC Name:
2-ethylhexyl methacrylate
Test material form:
liquid

Administration / exposure

Doses / concentrations
Remarks:
Doses / Concentrations:

Basis:

Results and discussion

Details on results:
Ethylhexyl methacrylate belonged to the group of compounds exhibiting the smallest changes; the observed changes in transition properties seemed to be related to biological activities.

Applicant's summary and conclusion