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Diss Factsheets

Toxicological information

Exposure related observations in humans: other data

Administrative data

Endpoint:
exposure-related observations in humans: other data
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
documentation insufficient for assessment

Data source

Reference
Reference Type:
publication
Title:
A new source of allergic contact dermatitis from UV-cured (meth)acrylate adhesive.
Author:
Brooke RCC, Beck MH
Year:
2002
Bibliographic source:
Contact Dermatitis 47(3): 179-180

Materials and methods

Type of study / information:
human - skin sensitization, case report
Principles of method if other than guideline:
A man with hand dermatitis had a business in replacement windows, including fixing decorative pieces of glass to a glass sheet using a two-stage UV-cured glue. The material safety data sheet indicated that the glue contained 2-Hydroxyethyl methacrylate (< 50 %) and Ethylhexyl methacrylate (< 37 %), respectively. Patch testing was conducted on several materials.
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
2-ethylhexyl methacrylate
EC Number:
211-708-6
EC Name:
2-ethylhexyl methacrylate
Cas Number:
688-84-6
Molecular formula:
C12H22O2
IUPAC Name:
2-ethylhexyl methacrylate
Test material form:
liquid

Results and discussion

Results:
Patch testing showed positive  reactions to the adhesive and several acrylates and methacrylates  including 2-Hydroxyethyl methacrylate. A patch test with Ethylhexyl  methacrylate was not performed separately. The latex gloves worn by the  subject had a low resistance to penetration by (meth)acrylates.

Applicant's summary and conclusion