Registration Dossier

Data platform availability banner - registered substances factsheets

Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Exposure related observations in humans: other data

Administrative data

Endpoint:
exposure-related observations in humans: other data
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
documentation insufficient for assessment

Data source

Reference
Reference Type:
publication
Title:
A new source of allergic contact dermatitis from UV-cured (meth)acrylate adhesive.
Author:
Brooke RCC, Beck MH
Year:
2002
Bibliographic source:
Contact Dermatitis 47(3): 179-180

Materials and methods

Type of study / information:
human - skin sensitization, case report
Principles of method if other than guideline:
A man with hand dermatitis had a business in replacement windows, including fixing decorative pieces of glass to a glass sheet using a two-stage UV-cured glue. The material safety data sheet indicated that the glue contained 2-Hydroxyethyl methacrylate (< 50 %) and Ethylhexyl methacrylate (< 37 %), respectively. Patch testing was conducted on several materials.
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
2-ethylhexyl methacrylate
EC Number:
211-708-6
EC Name:
2-ethylhexyl methacrylate
Cas Number:
688-84-6
Molecular formula:
C12H22O2
IUPAC Name:
2-ethylhexyl methacrylate
Test material form:
liquid

Results and discussion

Results:
Patch testing showed positive  reactions to the adhesive and several acrylates and methacrylates  including 2-Hydroxyethyl methacrylate. A patch test with Ethylhexyl  methacrylate was not performed separately. The latex gloves worn by the  subject had a low resistance to penetration by (meth)acrylates.

Applicant's summary and conclusion