2-ethylhexyl methacrylate

Exposure related observations in humans: other data

Administrative data

Endpoint:

exposure-related observations in humans: other data

Type of information:

experimental study

Adequacy of study:

other information

Reliability:

4 (not assignable)

Rationale for reliability incl. deficiencies:

documentation insufficient for assessment

Data source

Reference

Reference Type:

publication

Title:

A new source of allergic contact dermatitis from UV-cured (meth)acrylate adhesive.

Author:

Brooke RCC, Beck MH

Year:

2002

Bibliographic source:

Contact Dermatitis 47(3): 179-180

Materials and methods

Type of study / information:

human - skin sensitization, case report

Principles of method if other than guideline:

A man with hand dermatitis had a business in replacement windows, including fixing decorative pieces of glass to a glass sheet using a two-stage UV-cured glue. The material safety data sheet indicated that the glue contained 2-Hydroxyethyl methacrylate (< 50 %) and Ethylhexyl methacrylate (< 37 %), respectively. Patch testing was conducted on several materials.

GLP compliance:

not specified

Test material

Test material information

Constituent 1

Reference substance name:

2-ethylhexyl methacrylate

EC Number:

211-708-6

EC Name:

2-ethylhexyl methacrylate

Cas Number:

688-84-6

Molecular formula:

C12H22O2

IUPAC Name:

2-ethylhexyl methacrylate

Test material form:

liquid

Results and discussion

Results:

Patch testing showed positive  reactions to the adhesive and several acrylates and methacrylates  including 2-Hydroxyethyl methacrylate. A patch test with Ethylhexyl  methacrylate was not performed separately. The latex gloves worn by the  subject had a low resistance to penetration by (meth)acrylates.