Registration Dossier

Data platform availability banner - registered substances factsheets

Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: other routes
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Data from handbook or collection of data. Insufficient information to determine reliability.

Data source

Referenceopen allclose all

Reference Type:
publication
Title:
Toxicological and Pharmacological Actions of Methacrylate Monomers I: Effects on isolated perfused rabbit heart.
Author:
Mir GN, Lawrence WH, Autian J
Year:
1973
Bibliographic source:
J. Pharm. Sci. 62: 778-782
Reference Type:
publication
Title:
Information profiles on potential occupational hazards, Vol.II, Chemical classes, Methacrylic acid and its|esters
Year:
1979
Bibliographic source:
in: Syracuse Research Corp., NTIS Report PB81-148892

Materials and methods

GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
2-ethylhexyl methacrylate
EC Number:
211-708-6
EC Name:
2-ethylhexyl methacrylate
Cas Number:
688-84-6
Molecular formula:
C12H22O2
IUPAC Name:
2-ethylhexyl methacrylate
Test material form:
liquid
Specific details on test material used for the study:
2-ethylhexyl methacrylate

Test animals

Species:
mouse
Strain:
not specified
Sex:
not specified

Administration / exposure

Route of administration:
intraperitoneal

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
2 614 mg/kg bw

Applicant's summary and conclusion