Registration Dossier
Registration Dossier
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EC number: 203-603-9 | CAS number: 108-65-6
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
A GLP-study in Pimephales promelas and a non-GLP study in Oncorhynchus mykiss, both studies according or equivalent to OECD guideline 203 are available as key studies for propylene glycol methyl ether acetate. These studies are supported by a GLP-study in Oryzias latipes and a non-GLP study in Oncorhynchus mykiss.
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Effect concentration:
- 130 mg/L
Additional information
In an acute toxicity study with Oncorhynchus mykiss, based on the nominal concentrations of propylene glycol methyl ether acetate ranging from 100 to 1,000 mg/l, the 96 h-LC0 was determined to be 100 mg/l. The 96-hour LC100 was determined to be 180 mg/l. An approximation of the 96-hour LC50 can be made by calculating the geometric mean between 96-hour LC0 and 96-hour LC100. Using this approach an LC50 value of 134 mg/l was calculated. The no observed effect concentration (NOEC) was determined to be greater than 100 mg/l. A 96-hour LC50 of 161 mg/l was established in an acute toxicity study with Pimephales promelas, based on nominal concentrations. Another acute toxicity study with Oncorhynchus mykiss using exposure concentrations from 100 to 1,000 mg/l the 96-hour LC50 was determined to be 130 mg/l, based on nominal concentrations. The Environment Agency of Japan studied the acute toxicity of propylene glycol methyl ether acetate to Oryzias latipes under semi-static conditions during 96 hours. The maximum exposure concentration was 100 mg/l. Based on the nominal concentrations, the 96-hour LC50 was determined to be superior to 100 mg/l. The test report from the Environment Agency of Japan is not available.
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