Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 203-561-1 | CAS number: 108-21-4
Endpoint summary
Administrative data
Description of key information
Available acute toxicity values for isopropyl acetate are:
Oral LD50 (rat) - 3000, 6750, 10900, 14964 mg/kg. 7.07, 9.85, 10.4, 11.3ml/kg. Oral LD50 (mouse) - 6650mg/kg. Oral LD50 (rabbit): 6945
Inhalation 8-hr LC50 (rat) - 50,600 mg/m3 (reliable study). LC0 (30mins) >133,669mg/l. LC100 (4hrs) <133669mg/l
Dermal LD50, 24-hr occlusive exposure (rabbit) - >17.4 g/kg
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Dose descriptor:
- LD50
- Value:
- 6 750 mg/kg bw
Acute toxicity: via inhalation route
Endpoint conclusion
- Dose descriptor:
- LC50
- Value:
- 50 600 mg/m³ air
Additional information
Acute oral LD50 values have been reported for isopropyl acetate in rats, mice and rabbits. The reported LD50 values range from 3000 mg/kg to 14,964 mg/kg. The two most robust studies are in rabbits and rats and report very similar LD50 values of 6945 and 6750mg/kg respectively. Whilst all the data is quite old, it consistently shows that this substance has a low acute oral toxicity and this information is deemed sufficient to fulfill the requirements of this end point.
Acute inhalation LC50 values have been reported for isopropyl acetate in rats and mice. The key acute inhalation toxicity study of isopropyl acetate by Pozzani et al (1959) reported an 8 -hr LC50 value of 50,600 mg/m3 in rats. Another study observed no deaths following exposure of rats to a concentration of aroudn 133,000mg/m3 but 5 out of 6 animals died after 4 hours exposure.
The key acute dermal toxicity study of isopropyl acetate by Smyth et al (1954) reported an LD50 value of >20 ml/kg (>17.4 g/kg), (24 -hr occlusive exposure). This was the maximum dose that could be tested using the method.
Justification for classification or non-classification
Based on the available animal data, there is sufficient information available to determine that no classification is required for any route of acute exposure.
Based on limited data available for isopropyl acetate and similar substances (from both repeat and single exposure studies), classification is recommended warning that exposure to high concentrations of isopropyl acetate vapours may cause narcosis (STOT-SE category 3 under regulation 1272/2008. R67 unde directive 67/548).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
