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EC number: 266-039-2 | CAS number: 65997-03-7 The low boiling fraction obtained by the distillation of tall oil. Contains fatty acids such as palmitic, stearic, oleic and linoleic as well as neutral materials.
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- weight of evidence
- Study period:
- 2005/09/26-2005/10/07
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: The study was conducted according to the appropriate OECD test guideline, and in compliance with GLP using a related test substance.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 005
- Report date:
- 2005
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Deviations:
- no
- GLP compliance:
- yes
Test material
- Reference substance name:
- Tall-oil pitch
- EC Number:
- 232-414-4
- EC Name:
- Tall-oil pitch
- Cas Number:
- 8016-81-7
- IUPAC Name:
- 8016-81-7
- Details on test material:
- - Name of test material (as cited in study report): TALL OIL PITCH
- Physical state: Dark liquid
- Expiration date of the lot/batch: not stated
- Storage condition of test material: 10C-25C, in the dark
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Charles River Deutschland GmbH, D-97633 Sulzfeld.
- Age at study initiation: not reported
- Weight at study initiation: 1.8, 2.2 and 2.6kg
- Fasting period before study: no mention
- Housing: Individual caging in metal wire cages, Ehret GmbH, D-79312 Emmendingen, type KK 016R, 79cm x 59cm bottom area, 38cm height.
- Diet: Altromin 2123 maintenance diet for rabbits, rich in crude fiber, ad libitum
- Water: Tap water from an automatic watering system, ad libitum
- Acclimation period: 5 days for one rabbit, 12 days for the other two.
ENVIRONMENTAL CONDITIONS
- Temperature (°C): average of 19.6C
- Photoperiod (hrs dark / hrs light): 12/12
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- shaved
- Vehicle:
- unchanged (no vehicle)
- Controls:
- other: Untreated skin surrounding test area
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.5 ml
- Concentration (if solution): undiluted - Duration of treatment / exposure:
- 4 hours
- Observation period:
- 1, 24, 48 and 72 hours after patch removal.
- Number of animals:
- 3F
- Details on study design:
- TEST SITE
- Area of exposure: dorsal thoracal region, clipped free of hair
- coverage: 2.5 x 2.5 cm
- Type of wrap if used: gauze patch held in place by fixing them marginally with non irritating tapes.
REMOVAL OF TEST SUBSTANCE
- Washing (if done): The tapes with the patches and the collars were removed, residual test substance was wiped off using wet cellulose tissue.
- Time after start of exposure: 4 hours
SCORING SYSTEM: According to OECD.
Results and discussion
In vivo
- Irritant / corrosive response data:
- All calculated mean scores were 0 for erythema/eschar and oedema at 24, 48 and 72 hours.
- Other effects:
- No symptoms of systemic toxicity were observed in the animals during the test period.
There was a small increase in body weight for each of the animals. Animal 1: 1.8kg to 2.2kg, Animal 2: 2.6kg to 2.7kg, Animal 3: 2.2kg to 2.3 kg.
Residual test substance was noted on the exposed skin areas, resp. on the growing hair until 72h p.a.
Any other information on results incl. tables
There were no mortalities during the study.
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The test material was not irritant in a reliable study conducted according to an appropriate test protocol, and in compliance with GLP.
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