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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Description of key information

Based on available data for groups of constituents present in Tall Oil Heads, a conservative 2-year NOAEL of >200 mg/kg/d is set for the oral route. 

Key value for chemical safety assessment

Repeated dose toxicity: via oral route - systemic effects

Endpoint conclusion
Dose descriptor:
200 mg/kg bw/day
Study duration:

Additional information

No relevant repeated dose toxicity studies have been conducted for Tall Oil Heads (TOH) as whole product. However, data are available for the constituent parts of TOH and related substances (unpublished laboratory studies and information published in the public domain). The available data are summarised in the table below. Details are given in the attached expert report (PFA, 2010).

Constituent type

Proportion in TOH (%)

NOAEL (mg/kg/day, rat)



Fatty acids



90 days


Resin acids and neutrals



2 year

Weight of evidence from a number of 90-day and 2-year studies




90 days





28 days

OECD 422 study


These data are sufficient to demonstrate that none of the constituents of TOH require classification for specific target organ toxicity following repeated oral exposure, and to allow quantitative Derived No Effect Level to be set for risk characterisation.


No further testing for repeated dose toxicity is proposed for TOH.

Justification for classification or non-classification

The available data for constituents of TOH indicate that classification for specific target organ toxicity is not required.