Registration Dossier
Registration Dossier
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EC number: 212-660-9 | CAS number: 839-90-7
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: according to information in OECD SIDS (2002)
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 2 002
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Tris(2-hydroxyethyl)-1,3,5-triazinetrione
- EC Number:
- 212-660-9
- EC Name:
- Tris(2-hydroxyethyl)-1,3,5-triazinetrione
- Cas Number:
- 839-90-7
- Molecular formula:
- C9H15N3O6
- IUPAC Name:
- tris(2-hydroxyethyl)-1,3,5-triazinane-2,4,6-trione
- Details on test material:
- - Identity: Tris(2-hydroxyethyl) isocyanurate (CAS: 839-90-7)
- Source: Nissan Chemical Industries Ltd.; Lot No. 00915-1
- Purity: 99.0 %
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- - Age of the animals at study initiation: 5 weeks old
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Remarks:
- for injection
- Doses:
- 0, 500, 1,000, 2,000 mg/kg bw
- No. of animals per sex per dose:
- 5
- Control animals:
- yes
- Details on study design:
- Control animals comprised a concurrent vehicle control group
- Statistics:
- Not applicable, because of no fatality.
Results and discussion
Effect levels
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Mortality:
- None
- Clinical signs:
- other: No treatment related clinical sign observed.
- Gross pathology:
- No treatment-related abnormalities.
- Other findings:
- There was no treatment-related adverse effect.
Applicant's summary and conclusion
- Interpretation of results:
- other: LD50 > 2000 mg/kg body weight
- Conclusions:
- There were no treatment related abnormalities. LD50 is greater than 2,000 mg/kg for both sexes.
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