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Registration Dossier
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EC number: 203-854-4 | CAS number: 111-29-5
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Acceptable publication which meets basic scientific principles
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Reference
- Reference Type:
- publication
- Title:
- Range-Finding Toxicity Data: List VI
- Author:
- Smyth HF, Carpenter CP, Weil CS, Pozzani UC, Striegel JA .
- Year:
- 1 962
- Bibliographic source:
- Am Ind Hyg Assoc J 23: 95-107
Materials and methods
- Principles of method if other than guideline:
- According to Draize et al. 1944. J. Pharmacol. Exper. Therap. 82, 377
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- Pentane-1,5-diol
- EC Number:
- 203-854-4
- EC Name:
- Pentane-1,5-diol
- Cas Number:
- 111-29-5
- Molecular formula:
- C5H12O2
- IUPAC Name:
- pentane-1,5-diol
- Details on test material:
- - Name of test material (as cited in study report): 1,5-pentanediol
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: 2.5 - 3.5 kg
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- TEST SITE
- Type of wrap if used: impervious plastic film
- Site: fur was clipped
TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 20 ml
- Concentration (if solution): 100%
- Constant volume or concentration used: yes - Duration of exposure:
- 24 h
- Doses:
- not specified
- No. of animals per sex per dose:
- 4
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Statistics:
- calculation acc. to method of Thompson using the Tables of Weil.
Results and discussion
Effect levelsopen allclose all
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- > 20 mL/kg bw
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- > 19 800 mg/kg bw
Applicant's summary and conclusion
- Interpretation of results:
- practically nontoxic
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
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