Registration Dossier

Toxicological information

Skin sensitisation

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Administrative data

Endpoint:
skin sensitisation: in vitro
Type of information:
other: ongoing study
Adequacy of study:
supporting study
Study period:
2020-2022
Reliability:
other: ongoing guideline study
Justification for type of information:
In the course of a dossier improvement project the toxicological data set of 1,5-pentanediol will be extended and reviewed. Regarding the endpoint sensitisation, the in vitro studies OECD 442 C, D, E will be conducted. The results will be submitted as soon as the data are available, until then the ongoing study will be marked as supporting study.

Data source

Materials and methods

Test guidelineopen allclose all
Qualifier:
according to guideline
Guideline:
other: OECD Guideline 442E (In Vitro Skin Sensitisation: Activation of Dentritic Cells)
Qualifier:
according to guideline
Guideline:
OECD Guideline 442C (In Chemico Skin Sensitisation: Direct Peptide Reactivity Assay (DPRA))
Qualifier:
according to guideline
Guideline:
OECD Guideline 442D (In Vitro Skin Sensitisation: ARE-Nrf2 Luciferase Test Method)
GLP compliance:
yes
Type of study:
other: in vitro testing battery

Test material

Constituent 1
Chemical structure
Reference substance name:
Pentane-1,5-diol
EC Number:
203-854-4
EC Name:
Pentane-1,5-diol
Cas Number:
111-29-5
Molecular formula:
C5H12O2
IUPAC Name:
pentane-1,5-diol

Results and discussion

Applicant's summary and conclusion