Registration Dossier

Toxicological information

Toxicity to reproduction

Currently viewing:

Administrative data

Endpoint:
screening for reproductive / developmental toxicity
Type of information:
other: ongoing study
Adequacy of study:
supporting study
Study period:
2020-2021
Reliability:
other: ongoing guideline study
Justification for type of information:
In the course of a dossier improvement project the toxicological data set of 1,5-pentanediol will be extended and reviewed. Regarding the endpoint toxicity to reproduction, the screening study OECD 422 will be conducted. The results will be submitted as soon as the data are available, until then the ongoing study will be flagged as supporting study.

Data source

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 422 (Combined Repeated Dose Toxicity Study with the Reproduction / Developmental Toxicity Screening Test)
GLP compliance:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
Pentane-1,5-diol
EC Number:
203-854-4
EC Name:
Pentane-1,5-diol
Cas Number:
111-29-5
Molecular formula:
C5H12O2
IUPAC Name:
pentane-1,5-diol

Test animals

Species:
rat

Administration / exposure

Route of administration:
oral: gavage

Results and discussion

Applicant's summary and conclusion