Registration Dossier

Administrative data

Description of key information

Key value for chemical safety assessment

Skin sensitisation

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not sensitising)
Additional information:

Justification for read across for studies with sodium dichloroisocyanurate dihydrate:

The chlorinated isocyanurates (sodium dichloroisocyanurate and sodium dichloroisocynanurate dihydrate) produce free available chlorine, in the form of hypochlorous acid (HOCl) as they dissolve in water. As the equilibria involve all of the possible chlorinated isocyanurates, the toxicity of sodium dichloroisocyanurate (NaDCC) and sodium dichloroisocyanurate dihydrate (NaDCC.2H2O) will be virtually equivalent at the same available chlorine concentration. The parent compound for all chlorinated isocyanurates is isocyanuric acid (cyanuric acid). All of the chlorinated isocyanurates are essentially equivalent, once they are dissolved in water at the low concentrations at which they are used. Therefore read across from sodium dichloroisocyanurate dihydrate to troclosene sodium is justified.

A Guinea Pig Maximization study was performed with sodium dichloroisocyanurate dihydrate (Allen 2000) according to OECD guideline 406. Ten test animals and five control animals were used. Two phases were involved in the main study; an induction of a response by intradermal injection (0.1% w/v of test substance) and topical application and a topical challenge of that response. None of the animals elicited a positive response.


Migrated from Short description of key information:
Sodium dichloroisocyanurate dihydrate was not sensitizing in the OECD 406 guideline study. Read across to troclosene sodium is considered justified.

Respiratory sensitisation

Endpoint conclusion
Additional information:
Migrated from Short description of key information:
No data available

Justification for classification or non-classification

No positive responses were seen in the GPMT. Read across is considered justified to troclosene sodium and no classification for skin sensitisation is warranted.