Registration Dossier
Registration Dossier
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EC number: 701-480-0 | CAS number: -
Toxicological Summary
Administrative data
Workers - Hazard via inhalation route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- no-threshold effect and/or no dose-response information available
Acute/short term exposure
- Hazard assessment conclusion:
- no-threshold effect and/or no dose-response information available
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- no-threshold effect and/or no dose-response information available
Acute/short term exposure
- Hazard assessment conclusion:
- no-threshold effect and/or no dose-response information available
DNEL related information
Workers - Hazard via dermal route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- exposure based waiving
Acute/short term exposure
- Hazard assessment conclusion:
- exposure based waiving
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- exposure based waiving
Acute/short term exposure
- Hazard assessment conclusion:
- exposure based waiving
Workers - Hazard for the eyes
Local effects
- Hazard assessment conclusion:
- no hazard identified
Additional information - workers
Copper slag is a complex metal containing substance. It mainly contain iron silicate and silicates of aluminum and calcium. Traces of metals exist in metal, mineral form or included in silicate phases.
The toxicity and classification is therefore related to:
- Amount of metals present (%)
- Speciation of metals
- Degree to which the metal constituents react with water / biological fluids and release soluble, potentially bio available ionic and other metal bearing species.
- Rules for classification of mixtures as defined in the CLP regulation (2009)
Classification derived based on high quality test data on skin irritation, eye irritation, acute toxicity via oral and dermal route, bacterial gene mutation test and bacterial survival test.
Results demonstrate that:
- Copper slag is not skin irritant. The absence of irritation effects furthermore excludes the possibility for corrosion, defined as serious damage of tissues throughout the skin thickness.
- Copper slag is not harmful and not toxic via oral and dermal route.
- Copper slag is not mutagenic and does not affect bacteria survival.
Classification furthermore derived based on the rules for mixtures (CLP regulation).
Data from in vitro bio-accessibility tests in biological fluids ( gastric and sweat) are further used to refine /confirm the classification.
Conclusively based on consideration of toxicity data, chemical composition, speciation and reduced bio-accessibility, copper slags do not need classification for human health hazards.
A summary of the human health classification is attached.
Detailed explanation and justification are provided in records for every endpoint
General Population - Hazard via inhalation route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- no-threshold effect and/or no dose-response information available
Acute/short term exposure
- Hazard assessment conclusion:
- no-threshold effect and/or no dose-response information available
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- no-threshold effect and/or no dose-response information available
Acute/short term exposure
- Hazard assessment conclusion:
- no-threshold effect and/or no dose-response information available
DNEL related information
General Population - Hazard via dermal route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
General Population - Hazard via oral route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- no-threshold effect and/or no dose-response information available
Acute/short term exposure
- Hazard assessment conclusion:
- no-threshold effect and/or no dose-response information available
DNEL related information
General Population - Hazard for the eyes
Local effects
- Hazard assessment conclusion:
- no hazard identified
Additional information - General Population
Copper slag is a complex metal containing substance. It mainly contain iron silicate and silicates of aluminum and calcium. Traces of metals exist in metal, mineral form or included in silicate phases.
The toxicity and classification is therefore related to:
- Amount of metals present (%)
- Speciation of metals
- Degree to which the metal constituents react with water / biological fluids and release soluble, potentially bio available ionic and other metal bearing species.
- Rules for classification of mixtures as defined in the CLP regulation (2009)
Classification derived based on high quality test data on skin irritation, eye irritation, acute toxicity via oral and dermal route, bacterial gene mutation test and bacterial survival test.
Results demonstrate that:
- Copper slag is not skin irritant. The absence of irritation effects furthermore excludes the possibility for corrosion, defined as serious damage of tissues throughout the skin thickness.
- Copper slag is not harmful and not toxic via oral and dermal route.
- Copper slag is not mutagenic and does not affect bacteria survival.
Classification furthermore derived based on the rules for mixtures (CLP regulation).
Data from in vitro bio-accessibility tests in biological fluids ( gastric and sweat) are further used to refine /confirm the classification.
Conclusively based on consideration of toxicity data, chemical composition, speciation and reduced bio-accessibility, copper slags do not need classification for human health hazards.
A summary of the human health classification is attached.
Detailed explanation and justification are provided in records for every endpoint
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