Registration Dossier
Registration Dossier
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EC number: 701-480-0 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Well documented study performed according to internationally accepted method
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 001
- Report date:
- 2001
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.5 (Acute Toxicity: Eye Irritation / Corrosion)
- Deviations:
- no
- Principles of method if other than guideline:
- Study was performed to evaluate the potential irritant effects of copper slag on the mucous membranes (eyes) based on EU B5 method - Acute toxicity - eye irritation. The test substance was applied in a single dose in an animal's eye using the other eye as control.
- GLP compliance:
- no
- Remarks:
- other quality assurance
Test material
- Reference substance name:
- Iron silicate, copper smelting and refining
- EC Number:
- 701-480-0
- Cas Number:
- 67711-92-6
- IUPAC Name:
- Iron silicate, copper smelting and refining
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or tissues and environmental conditions:
- Rabbit healthy adult male albino
The diet was standard for this type of animal. The animal house temperature was maintained at 20 + / - 2C, the relative humidity was between 30-70% and photoperiod was 12/12 hours light / dark.
Test system
- Controls:
- yes, concurrent no treatment
- Duration of treatment / exposure:
- Single dose
- Observation period (in vivo):
- 24, 48 and 72 hours
- Number of animals or in vitro replicates:
- 1
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- cornea opacity score
- Time point:
- 24/48/72 h
- Score:
- 0
- Remarks on result:
- other: No ulceration or opacity
- Irritation parameter:
- iris score
- Time point:
- 24/48/72 h
- Score:
- 0
- Remarks on result:
- other: Normal
- Irritation parameter:
- conjunctivae score
- Time point:
- 24/48/72 h
- Score:
- 0
- Remarks on result:
- other: Normal blood vessels
- Irritation parameter:
- chemosis score
- Time point:
- 24/48/72 h
- Score:
- 0
- Remarks on result:
- other: No swelling
Applicant's summary and conclusion
- Interpretation of results:
- irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Good quality study. the sample is not eye irrutant.
- Executive summary:
Study was performed to evaluate the potential irritant effects of copper slag on the mucous membranes (eyes) based on EU B5 method - Acute toxicity - eye irritation
Based on the results, copper slag is not eye irritant.
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