slag, copper smelting

Respiratory sensitisation

Administrative data

Endpoint:

respiratory sensitisation

Remarks:

other: prediction from hazard class

Type of information:

calculation (if not (Q)SAR)

Remarks:

Migrated phrase: estimated by calculation

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Automatic calculation tool with MeClas tool

Cross-reference

Reason / purpose for cross-reference:

reference to other study

Data source

Reference

Reference Type:

other: software

Title:

Unnamed

Year:

2019

Materials and methods

Principles of method if other than guideline:

The potential of the UVCB substance as respirsatory sensitiser was established by classifying the complex metal substance according to rules for classification of mixtures for respiratory or skin sensitisation (EU CLP guidance section 3.4.3 pg 277ff). The classification criteria (as set out in EU CLP Annex I: 3.4.3.3.1.) can be used to estimate effects derived from that classification/hazard.

GLP compliance:

no

Remarks:

other quality assurance

Test material

Test material information

Constituent 1

Reference substance name:

Iron silicate, copper smelting and refining

EC Number:

701-480-0

Cas Number:

67711-92-6

IUPAC Name:

Iron silicate, copper smelting and refining

Details on test material:

Typical (across industry) copper slag as defined in section 1.2 ;
See IUCLID Section 1.4, for company specific elemental composition; and representative sample for mineralogical information (IUCLID Section 4.23 -Outotec report)

Results and discussion

Any other information on results incl. tables

The calculated classification via mixture toxicity rules resulted in “Respiratory sensitization: Not classified”

Copper slag contains minor constituents classified as respiratory sensitisers but their actual levels are much lower than < 1% thus Mixture A is not classified for respiratory sensitization.

Applicant's summary and conclusion

Interpretation of results:

not sensitising

Remarks:

predicted effect

Conclusions:

Result can be used to predict respiratory sensitizing effect and to classify the UVCB substance

Executive summary:

The study provided a conservative estimate of the Respiratory sensitization effect,derived on basis of the Classification outcome by applying the rules for mixtures of a Typical (across industry) copper slag.

It is concluded that slag, copper smelting is not to be classified as respiratory sensitizer..

The result is applicable to all copper slags that fall under the defined concentration ranges (IUCLID section 1.2).

Chemistry of the substance (see IUCLID section 4.23 chemical and mineralogical characterization) shows that no significant amounts of Respiratory Sensitizer species detected in representative samples and maximim across industry.