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EC number: 200-909-4 | CAS number: 75-86-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Comparable to guideline study with acceptable restrictions. Range-finding test.
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 962
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Range-finding test
Groups of 6 albino rats were exposed to 2-hydroxy-2-methylpopionitrile vapors that were produced by passing a 2.5-l/min-air stream through a
fritted glass disc immersed in 50 ml acetone cyanohydrin. Doses were logarithmically distributed, differing by a factor of two (doses were not stated
explicitly). Exposure period was 4 hours. The observation period was 14 days. - GLP compliance:
- no
- Remarks:
- study performed before implementation of GLP
- Test type:
- other: Range-finding test
- Limit test:
- no
Test material
- Reference substance name:
- 2-hydroxy-2-methylpropionitrile
- EC Number:
- 200-909-4
- EC Name:
- 2-hydroxy-2-methylpropionitrile
- Cas Number:
- 75-86-5
- Molecular formula:
- C4H7NO
- IUPAC Name:
- 2-hydroxy-2-methylpropanenitrile
- Details on test material:
- - Name of test material (as cited in study report): alpha-Hydroxyisobutyronitrile (no further information)
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: Albino
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- no data
Administration / exposure
- Route of administration:
- inhalation: vapour
- Type of inhalation exposure:
- not specified
- Details on inhalation exposure:
- Rats were epose to acetone cyanohydrin vapors that were produced by passing a 2.5-L/min-air stream through a fritted glass disc immersed in
50 mL acetone cyanohydrin. Doses were logarithmically distributed, differing by a factor of two (doses were not stated explicitly). - Analytical verification of test atmosphere concentrations:
- no
- Duration of exposure:
- 4 h
- Concentrations:
- Doses were logarithmically distributed, differing by a factor of two (doses were not stated explicitly).
- No. of animals per sex per dose:
- 6 animals per dose
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: no data
- Necropsy of survivors performed: no data
- Other examinations performed: clinical signs, body weight,organ weights, histopathology, other: no data
Results and discussion
Effect levelsopen allclose all
- Sex:
- not specified
- Dose descriptor:
- LCLo
- Effect level:
- 62.5 ppm
- Exp. duration:
- 4 h
- Remarks on result:
- other: 5 min caused no death, 62.5 ppm (equals 0.223 mg/L) 2/6 rats died after 4 hours
- Sex:
- not specified
- Dose descriptor:
- LC100
- Effect level:
- 125 ppm
- Exp. duration:
- 4 h
- Remarks on result:
- other: 6/6 rats died, 125 ppm (equals 0.446 mg/L (446 mg/m³/4hr))
- Mortality:
- 5 min of exposure:
62.5 ppm: no death (0/6 rats died after 5 min of exposure)
4 hour exposure:
62.5 ppm: 2/6 rats
125 ppm: 6/6 rats - Clinical signs:
- other: No other signs of toxicity were reported.
- Body weight:
- no data
- Gross pathology:
- no data
Any other information on results incl. tables
No NOEL established.
Applicant's summary and conclusion
- Interpretation of results:
- Category 2 based on GHS criteria
- Remarks:
- Migrated information
- Conclusions:
- Legally binding harmonised classification as given in REGULATION (EC) No 1272/2008 Annex VI Table 3.1 (GHS): Acute tox. 2*; H330 and Table 3.2 (Annex I of Directive 67/548/EEC): T+; R26/27/28.
- Executive summary:
Groups of 6 albino rats were exposed to 2-hydroxy-2-methylpopionitrile vapors that were produced by passing a 2.5-l/min-air stream through a fritted glass disc immersed in 50 ml acetone cyanohydrin. Doses were logarithmically distributed, differing by a factor of two (doses were not stated explicitly). The observation period was 14 days. After exposure for 4 hours, 2/6 rats were killed at 62.5ppm and 6/6 rats were killed at 125 ppm. No other signs of toxicity were reported.
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