Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
developmental toxicity
Adequacy of study:
other information

Data source

Referenceopen allclose all

Title:
No information
Author:
Berteau PE, Levinskas GJ, Rodwell ED. (1982)|Teratogenic effects of aliphatic nitriles in rats.|Toxicologist 2(1) 118
Title:
No information
Author:
Monsanto Co. (1982)|Range finding teratology study in the rat: Monsanto Co.|Report IL-83-094. US EPA/OPTS Public file No. 878216399.
Title:
No information
Author:
Monsanto Co. (1983)|Report IL-83-105 Teratology study in rats US EPA/OPTS Public|files No. 878216401

Materials and methods

Principles of method if other than guideline:
Method: other
GLP compliance:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
2-hydroxy-2-methylpropionitrile
EC Number:
200-909-4
EC Name:
2-hydroxy-2-methylpropionitrile
Cas Number:
75-86-5
Molecular formula:
C4H7NO
IUPAC Name:
2-hydroxy-2-methylpropanenitrile
Details on test material:
IUCLID4 Test substance: as prescribed by 1.1 - 1.4

Test animals

Species:
rat

Administration / exposure

Route of administration:
oral: gavage
Frequency of treatment:
daily (gd 6 through 15)
Doses / concentrations
Remarks:
Doses / Concentrations:
1, 3 & 10 mg/kg/day
Basis:

Control animals:
yes, concurrent vehicle
Details on study design:
Sex: female
Duration of test: 9 days

Results and discussion

Results: maternal animals

Effect levels (maternal animals)

Dose descriptor:
NOAEL
Effect level:
1 mg/kg bw/day
Basis for effect level:
other: maternal toxicity

Results (fetuses)

Effect levels (fetuses)

Dose descriptor:
NOAEL
Effect level:
10 mg/kg bw/day
Basis for effect level:
other: teratogenicity

Fetal abnormalities

Abnormalities:
not specified

Overall developmental toxicity

Developmental effects observed:
not specified

Applicant's summary and conclusion

Executive summary:

NOTE: Any of data in this dataset are disseminated by the European Union on a right-to-know basis and this is not a publication in the same sense as a book or an article in a journal. The right of ownership in any part of this information is reserved by the data owner(s). The use of this information for any other, e.g. commercial purpose is strictly reserved to the data owners and those persons or legal entities having paid the respective access fee for the intended purpose.